ENOPH1 - enolase-phosphatase 1 Gene

Also Known as E1; MASA; mtnC; MST145

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58478

About ENOPH1

This gene has 3 transcripts (splice variants) and 226 orthologues. Ubiquitous expression in brain (RPKM 34.5), thyroid (RPKM 16.6) and 25 other tissues.

Summary

Enables acireductone synthase activity. Involved in L-methionine salvage from methylthioadenosine. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ENOPH1 Products (2)

mRNA Protein Name
NM_001292017.2 NP_001278946.1 enolase-phosphatase E1 isoform 2
NM_021204.5 NP_067027.1 enolase-phosphatase E1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables acireductone synthase activity IDA
IDA: Inferred from direct assay
15843022 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in L-methionine salvage from methylthioadenosine IDA
IDA: Inferred from direct assay
15843022 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENOPH1 Protein Structure

HAD_2

HAD_2: Haloacid dehalogenase-like hydrolase (13 - 229)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

enolase-phosphatase E1

  • 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

ENOPH1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ENOPH1 Q9UHY7 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
32296183
Intra
ENOPH1 Q9UHY7 RNF41 Homo sapiens Q9H4P4
Y2H Array
32296183
Intra
ENOPH1 Q9UHY7 RNF41 Homo sapiens Q9H4P4
Anti Tag CoIP
28514442
Intra
ENOPH1 Q9UHY7 RNF41 Homo sapiens Q9H4P4
Anti Tag CoIP
33961781
Intra
ENOPH1 Q9UHY7 ZNF280A Homo sapiens P59817
Y2H Prey Pooling
32296183
Intra
ENOPH1 Q9UHY7 ZNF280A Homo sapiens P59817
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 4q21 Deletion Syndrome

  • 4q21 Microdeletion Syndrome

  • Monosomy 4q21

  • Del(4)(Q21)

  • Chromosome Deletion Syndrome 4q21
Malignant Hemangioma
Atrial Septal Defect 1

  • ASD1

  • Atrial Heart Septal Defect 1

  • Asd
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04382 ENOPH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ENOPH1 MGD MGI:1915120
Rattus norvegicus ENOPH1 RGD RGD:1309016
Felis catus ENOPH1 VGNC VGNC:107330
Canis familiaris ENOPH1 VGNC VGNC:40369
Bos taurus ENOPH1 VGNC VGNC:28500
Others ENOPH1 NCBI