Grb14 - growth factor receptor bound protein 14 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58844

Summary

Enables phosphoprotein binding activity. Involved in several processes, including Insulin Receptor signaling pathway; negative regulation of Insulin Receptor signaling pathway; and negative regulation of meiotic cell cycle process involved in oocyte maturation. Located in Golgi apparatus; endosome; and plasma membrane. Orthologous to human GRB14 (growth factor receptor bound protein 14). [provided by Alliance of Genome Resources, Apr 2022]

Grb14 Products (1)

mRNA Protein Name
NM_031623.2 NP_113811.2 growth factor receptor-bound protein 14

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
9748281 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20932831 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
14623073 RGD
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
9748281 RGD
involved in intracellular signal transduction IEP
IEP: Inferred from expression pattern
9748281 RGD
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
9748281 RGD
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18657188 RGD
involved in negative regulation of meiotic cell cycle process involved in oocyte maturation IMP
IMP: Inferred from mutant phenotype
14623073 RGD
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
18657188 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth factor receptor-bound protein 14

  • GRB14 adapter protein

Grb14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Grb14 O88900 FGFR1 Homo sapiens P11362
BRET
20932831
Cross
Grb14 O88900 FGFR1 Homo sapiens P11362
Anti Tag CoIP
20932831
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05779 GRB14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grb14 NCBI NCBI:2888