RGS3 - regulator of G protein signaling 3 Gene

Also Known as C2PA; RGP3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5998

About RGS3

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:113,444,730-113,597,738 (from NCBI)

This gene has 31 transcripts (splice variants), 344 orthologues and 23 paralogues. Ubiquitous expression in heart (RPKM 8.0), fat (RPKM 4.2) and 24 other tissues.

Summary

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]

RGS3 Products (14)

mRNA Protein Name
NM_001276260.2 NP_001263189.1 regulator of G-protein signaling 3 isoform 2
NM_001276261.2 NP_001263190.1 regulator of G-protein signaling 3 isoform 7
NM_001276262.2 NP_001263191.1 regulator of G-protein signaling 3 isoform 4
NM_001282922.2 NP_001269851.1 regulator of G-protein signaling 3 isoform 2
NM_001282923.2 NP_001269852.1 regulator of G-protein signaling 3 isoform 8 precursor
NM_001322214.3 NP_001309143.1 regulator of G-protein signaling 3 isoform 9
NM_001322215.2 NP_001309144.1 regulator of G-protein signaling 3 isoform 10
NM_001351526.2 NP_001338455.1 regulator of G-protein signaling 3 isoform 2
NM_001394167.1 NP_001381096.1 regulator of G-protein signaling 3 isoform 11
NM_017790.6 NP_060260.3 regulator of G-protein signaling 3 isoform 3
NM_130795.4 NP_570613.2 regulator of G-protein signaling 3 isoform 1
NM_134427.3 NP_602299.1 regulator of G-protein signaling 3 isoform 4
NM_144488.8 NP_652759.4 regulator of G-protein signaling 3 isoform 12
NM_144489.4 NP_652760.3 regulator of G-protein signaling 3 isoform 5

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS3 Protein Structure

C2

C2: C2 domain (153 - 235)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (300 - 372)

RGS

RGS: Regulator of G protein signaling domain (1073 - 1188)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1198 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 3

  • regulator of G-protein signalling 3

RGS3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RGS3 P49796 ACD Homo sapiens Q96AP0
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11919 RGS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21422 Rgs3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27940 Rgs3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RGS3 MGD MGI:1354734
Felis catus RGS3 VGNC VGNC:82500
Bos taurus RGS3 VGNC VGNC:33922
Rattus norvegicus RGS3 RGD RGD:3566
Macaca mulatta RGS3 VGNC VGNC:76920
Canis familiaris RGS3 VGNC VGNC:45533
Others RGS3 NCBI