Npff - neuropeptide FF-amide peptide precursor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60337

Summary

Enables G protein-coupled receptor binding activity and neuropeptide hormone activity. Involved in several processes, including ion homeostasis; negative regulation of Insulin secretion; and peptide hormone secretion. Located in several cellular components, including axon terminus; dendrite; and perikaryon. Orthologous to human NPFF (neuropeptide FF-amide peptide precursor). [provided by Alliance of Genome Resources, Apr 2022]

Npff Products (1)

mRNA Protein Name
NM_022586.1 NP_072108.1 pro-FMRFamide-related neuropeptide FF preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor binding IDA
IDA: Inferred from direct assay
11024015 RGD
enables neuropeptide hormone activity IDA
IDA: Inferred from direct assay
11984823 RGD
Biological Process GO Annotation Evidence References Source
involved in acute inflammatory response to antigenic stimulus IEP
IEP: Inferred from expression pattern
15207282 RGD
involved in excitatory postsynaptic potential IDA
IDA: Inferred from direct assay
10938301 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
12619141 RGD
involved in negative regulation of appetite IDA
IDA: Inferred from direct assay
8801545 RGD
involved in negative regulation of heart rate IDA
IDA: Inferred from direct assay
8680863 RGD
involved in negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
1704109 RGD
involved in positive regulation of blood pressure IDA
IDA: Inferred from direct assay
8680863 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
11024015 RGD
involved in regulation of membrane depolarization IDA
IDA: Inferred from direct assay
17289819 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16529722 RGD
involved in somatostatin secretion IDA
IDA: Inferred from direct assay
1704109 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
12619141 RGD
involved in vasopressin secretion IDA
IDA: Inferred from direct assay
8612481 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
1924889 RGD
located in dendrite IDA
IDA: Inferred from direct assay
1924889 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
7891084 RGD
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
1924889 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
1924889 RGD
located in vesicle IDA
IDA: Inferred from direct assay
1924889 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-FMRFamide-related neuropeptide FF

  • FMRFamide-related peptides

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107726 BIBP3226 TFA Antagonist 99.92% Unkown
HY-P1248 Neuropeptide FF 99.35% Unkown
HY-P1428 RFRP-1(human) Agonist 99.00% Unkown
HY-P10377 GUB03385 Agonist 97.75% Unkown
HY-P1245 Neuropeptide SF (human) Activator 99.78% Unkown
HY-P1250 RFRP-3(human) Agonist 99.43% Unkown
HY-107726A BIBP3226 Antagonist 98.78% Unkown
HY-161405 NPFF1-R antagonist 1 Inhibitor 99.38% Unkown
HY-P10380A palm11-PrRP31 TFA Agonist 99.44% Unkown
HY-154829A AC-099 hydrochloride Agonist 99.92% Unkown
HY-P10379 palm-PrRP31 Agonist / Unkown
HY-P10380 palm11-PrRP31 Agonist / Unkown
HY-P11810 GUB08248 Agonist / Unkown
HY-P1245A Neuropeptide SF (human) acetate Activator / Unkown
HY-P1249 Neuropeptide SF(mouse,rat) Agonist / Unkown
HY-P1249A Neuropeptide SF(mouse,rat) TFA Agonist / Unkown
HY-P1250A RFRP-3(human) TFA Agonist / Unkown
HY-P1428A RFRP-1(human) TFA Agonist / Unkown
HY-P3843 Neuropeptide AF (cattle) Agonist / Unkown
HY-RS09480 NPFF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-154829 AC-099 Agonist / Unkown
HY-161382 NPFF2-R ligand 1 Ligand / Unkown
HY-RS16912 Npff Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23354 Npff Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npff NCBI NCBI:8620