NPFF - neuropeptide FF-amide peptide precursor Gene

Also Known as FMRFAL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8620

About NPFF

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,506,688-53,507,484 (from NCBI)

This gene has 2 transcripts (splice variants) and 148 orthologues. Ubiquitous expression in skin (RPKM 3.8), spleen (RPKM 2.1) and 24 other tissues.

Summary

This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

NPFF Products (2)

mRNA Protein Name
NM_001320296.2 NP_001307225.1 pro-FMRFamide-related neuropeptide FF isoform 2
NM_003717.4 NP_003708.1 pro-FMRFamide-related neuropeptide FF isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables neuropeptide activity IDA
IDA: Inferred from direct assay
11024015 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
11024015 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPFF Protein Structure

NPFF

NPFF: Neuropeptide FF (31 - 113)

  • 0
  • 100
  • 113 a.a.
Protein Preferred Names Protein Names

pro-FMRFamide-related neuropeptide FF

Related Diseases

Diseases Alias
Migraine With Aura

  • Classic Migraine

  • Migraine With Typical Aura

  • Migraine Accompagnée

  • Complicated Migraine

  • Classical Migraine

  • Acute Migraine With Aura
Opiate Dependence

  • Opioid Dependence

  • Opioid Addiction

  • Opiate Addiction

  • Opioid Type Dependence

  • Opioid-Related Disorders

  • Opium Dependence

  • Narcotic Dependence

  • Intravenous Narcotism

  • Narcotism Nos

  • Oral Narcotism Nos
Postsurgical Hypothyroidism

  • Postoperative Hypothyroidism

  • Post-Surgical Hypothyroidism
Pain Agnosia

  • Analgesia
N Syndrome

  • NSX

  • Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia
Withdrawal Disorder

  • Withdrawal Syndrome

  • Substance Withdrawal Syndrome
Agnosia

  • Dyspraxia

  • Primary Visual Agnosia

  • Dyspraxia Syndrome

  • Monomodal Visual Amnesia

  • Visual Amnesia

  • Agnosia, Primary Visual

  • Apraxias

  • Alexia
Opioid Abuse

  • Opioid-Related Disorders
Hermansky-Pudlak Syndrome 3

  • HPS3

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Delta Storage Pool Disease

  • Hermansky-Pudlak Syndrome, Type 3

  • Platelet Storage Pool Deficiency

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107726 BIBP3226 TFA Antagonist 99.92% Unkown
HY-P1248 Neuropeptide FF 99.35% Unkown
HY-P1428 RFRP-1(human) Agonist 99.00% Unkown
HY-P10377 GUB03385 Agonist 97.75% Unkown
HY-P1245 Neuropeptide SF (human) Activator 99.78% Unkown
HY-P1250 RFRP-3(human) Agonist 99.43% Unkown
HY-107726A BIBP3226 Antagonist 98.78% Unkown
HY-161405 NPFF1-R antagonist 1 Inhibitor 99.38% Unkown
HY-P10380A palm11-PrRP31 TFA Agonist 99.44% Unkown
HY-154829A AC-099 hydrochloride Agonist 99.92% Unkown
HY-P10379 palm-PrRP31 Agonist / Unkown
HY-P10380 palm11-PrRP31 Agonist / Unkown
HY-P11810 GUB08248 Agonist / Unkown
HY-P1245A Neuropeptide SF (human) acetate Activator / Unkown
HY-P1249 Neuropeptide SF(mouse,rat) Agonist / Unkown
HY-P1249A Neuropeptide SF(mouse,rat) TFA Agonist / Unkown
HY-P1250A RFRP-3(human) TFA Agonist / Unkown
HY-P1428A RFRP-1(human) TFA Agonist / Unkown
HY-P3843 Neuropeptide AF (cattle) Agonist / Unkown
HY-RS09480 NPFF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-154829 AC-099 Agonist / Unkown
HY-161382 NPFF2-R ligand 1 Ligand / Unkown
HY-RS16912 Npff Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23354 Npff Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NPFF RGD RGD:62033
Mus musculus NPFF MGD MGI:1891708
Bos taurus NPFF VGNC VGNC:32198
Others NPFF NCBI