AMPH - Amph amphiphysin Gene

Also Known as Amph1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60668

Summary

Enables protein C-terminus binding activity. Involved in positive regulation of GTPase activity and positive regulation of endocytosis. Located in axon terminus. Is extrinsic component of synaptic vesicle membrane. Orthologous to human AMPH (amphiphysin). [provided by Alliance of Genome Resources, Apr 2022]

AMPH Products (1)

mRNA Protein Name
NM_022217.2 NP_071553.2 amphiphysin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatase binding IPI
IPI: Inferred from physical interaction
11498538 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9341169 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9348539 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
9348539 RGD
involved in positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
9348539 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
9348539 RGD
is active in extrinsic component of synaptic vesicle membrane IDA
IDA: Inferred from direct assay
1628617 RGD
is active in postsynaptic endocytic zone IDA
IDA: Inferred from direct assay
35072626 RGD
is active in postsynaptic endocytic zone IMP
IMP: Inferred from mutant phenotype
35072626 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

amphiphysin

  • amphiphysin 1

AMPH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Amph O08838 Dnm2 Rattus norvegicus P39052
Pull Down
16325581
Intra
Amph O08838 Bin1 Rattus norvegicus O08839
CoIP
9348539
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14327 FAUC 213 Antagonist 99.54% Unkown
HY-RS00669 AMPH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18227 Amph Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24705 Amph Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens AMPH NCBI NCBI:273