RPE - ribulose-5-phosphate-3-epimerase Gene

Homo sapiens

Also known as RPE2-1

Gene ID: 6120 | Gene type: protein coding

About RPE

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:210,002,638-210,022,260 (from NCBI)

This gene has 16 transcripts (splice variants), 227 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 5.9), adrenal (RPKM 5.7) and 25 other tissues.

Summary

Enables metal ion binding activity; protein homodimerization activity; and ribulose-phosphate 3-epimerase activity. Involved in carbohydrate metabolic process and pentose-phosphate shunt. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

RPE Products(14)

mRNA	Protein	Name
NM_001278282.2	NP_001265211.1	ribulose-phosphate 3-epimerase isoform 2
NM_001278283.2	NP_001265212.1	ribulose-phosphate 3-epimerase isoform 2
NM_001278285.2	NP_001265214.1	ribulose-phosphate 3-epimerase isoform 3
NM_001278286.2	NP_001265215.1	ribulose-phosphate 3-epimerase isoform 4
NM_001278288.2	NP_001265217.1	ribulose-phosphate 3-epimerase isoform 4
NM_001278289.2	NP_001265218.1	ribulose-phosphate 3-epimerase isoform 5
NM_001318926.2	NP_001305855.1	ribulose-phosphate 3-epimerase isoform 6
NM_001318927.2	NP_001305856.1	ribulose-phosphate 3-epimerase isoform 7
NM_001318928.2	NP_001305857.1	ribulose-phosphate 3-epimerase isoform 8
NM_001318929.2	NP_001305858.1	ribulose-phosphate 3-epimerase isoform 9
NM_001318930.2	NP_001305859.1	ribulose-phosphate 3-epimerase isoform 4
NM_001318931.2	NP_001305860.1	ribulose-phosphate 3-epimerase isoform 4
NM_006916.3	NP_008847.1	ribulose-phosphate 3-epimerase isoform 2
NM_199229.3	NP_954699.1	ribulose-phosphate 3-epimerase isoform 1

RPE Protein Structure

Ribul_P_3_epim

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

ribulose-phosphate 3-epimerase

Recombinant RPE Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71264	RPE Protein, Human (His)	Q96AT9-1 (M1-R228)	≥95%
HY-P74592	RPE Protein, Human (HEK293, His)	Q96AT9 (M1-R228)	≥95%

Related Diseases

Diseases

Alias

Myasthenic Syndrome, Congenital, 10

Congenital Myasthenic Syndrome 10	CMS10
Lgm	Myasthenia, Limb-Girdle, Familial
Myasthenia, Limb-Girdle, Familial, Formerly	Lgm, Formerly
Congenital Myasthenic Syndrome Type Ib, Formerly	Cms1b, Formerly
Cms Ib, Formerly	Myasthenic Myopathy, Formerly
Familial Limb-Girdle Myasthenia	Cms1b
Cms Ib	Congenital Myasthenic Syndrome Type 1b
Congenital Myasthenic Syndrome Type Ib	Myasthenic Myopathy
Myasthenic Syndrome, Congenital, Type 10	Congenital Myasthenic Syndrome Ib
Myopathy In Myasthenia Gravis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148457	Avacincaptad pegol	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-125639	(rac)-AR-13503	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134928A	Pyridinium bisretinoid A2E TFA		≥90.0%	Unkown
HY-N0428	Obacunone	Inducer	99.75%	Unkown
HY-12462	WS3		98.00%	Unkown
HY-101293	VU0359595	Inhibitor	99.65%	Unkown
HY-D0988	R-PE (R-Phycoerythrin)		/	Unkown
HY-22024	5-Hydroxyflavone		99.91%	Unkown
HY-134928	Pyridinium bisretinoid A2E		/	Unkown
HY-P5169A	LVGRQLEEFL (mouse) (TFA)		98.20%	Unkown
HY-151872	HDAC-IN-48		/	Unkown
HY-149325	RPE65-IN-1		/	Unkown
HY-D1742	DRAQ5	Chemical	/	Unkown
HY-N11499	Myricetin 3-O-α-L-arabinopyranoside	Inhibitor	/	Unkown
HY-P4253	Arginyl-Glutamine	Inhibitor	/	Unkown
HY-P5169	LVGRQLEEFL (mouse)		/	Unkown
HY-RS12150	RPE Human Pre-designed siRNA Set A		/	Unkown
HY-RS12151	RPE65 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPE	MGD	MGI:1913896
Rattus norvegicus	RPE	RGD	RGD:1564890
Macaca mulatta	RPE	NCBI

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