MRPL23 - mitochondrial ribosomal protein L23 Gene

Also Known as RPL23; uL23m; L23MRP; RPL23L

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 6150

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. [provided by RefSeq, Jul 2008]

MRPL23 Products (1)

mRNA Protein Name
NR_174403.1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
part of mitochondrial large ribosomal subunit IDA
IDA: Inferred from direct assay
25278503 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
28892042 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

large ribosomal subunit protein uL23m

  • 39S ribosomal protein L23, mitochondrial

  • L23 mitochondrial-related protein

  • L23mt

  • MRP-L23

  • mitochondrial large ribosomal subunit protein uL23m

  • ribosomal protein related to L23 (mitochondrial)

MRPL23 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MRPL23 Q16540 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
MRPL23 Q16540 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
MRPL23 Q16540 PNMA1 Homo sapiens Q8ND90
Validated Y2H
25416956
Intra
MRPL23 Q16540 PNMA1 Homo sapiens Q8ND90
Y2H Array
25416956
Intra
MRPL23 Q16540 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
MRPL23 Q16540 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
MRPL23 Q16540 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra
MRPL23 Q16540 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
MRPL23 Q16540 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08667 MRPL20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08668 MRPL28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08669 MRPL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08670 MRPL32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08680 MRPS23 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12175 RPL23 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16400 MRPL21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16434 MRPL13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21039 Rpl23 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21157 Mrpl21 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21889 Mrpl13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22650 Mrpl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27556 Rpl23 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27673 Mrpl21 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28406 Mrpl13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29164 Mrpl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown