2. Gene
  3. RTKN - rhotekin Gene

RTKN - rhotekin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 6242 | Gene type: protein coding

About RTKN

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,425,835-74,441,937 (from NCBI)

This gene has 11 transcripts (splice variants), 259 orthologues and 2 paralogues. Broad expression in kidney (RPKM 18.1), brain (RPKM 12.5) and 23 other tissues.

Summary

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of Cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RTKN Products(4)

mRNA Protein Name
NM_001015055.2 NP_001015055.1 rhotekin isoform a
NM_001015056.1 NP_001015056.1 rhotekin isoform c
NM_001410843.1 NP_001397772.1 rhotekin isoform d
NM_033046.2 NP_149035.1 rhotekin isoform b

RTKN Protein Structure

Anillin

Anillin: Cell division protein anillin (116 - 270)

PH

PH: PH domain (313 - 412)

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  • 563 a.a.
Protein Preferred Names Protein Names

rhotekin

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12320 RTKN Human Pre-designed siRNA Set A / Unkown
HY-RS12321 RTKN2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RTKN VGNC VGNC:76943
Mus musculus RTKN MGD MGI:107371
Rattus norvegicus RTKN RGD RGD:727874
Canis familiaris RTKN VGNC VGNC:45789
Bos taurus RTKN VGNC VGNC:34197
Felis catus RTKN VGNC VGNC:64807