SFSWAP - splicing factor SWAP Gene

Also Known as SWAP; SFRS8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6433

About SFSWAP

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:131,711,090-131,799,738 (from NCBI)

This gene has 11 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 11.1), spleen (RPKM 9.4) and 25 other tissues.

Summary

This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]

SFSWAP Products (2)

mRNA	Protein	Name
NM_001261411.2	NP_001248340.1	splicing factor, suppressor of white-apricot homolog isoform 1
NM_004592.4	NP_004583.2	splicing factor, suppressor of white-apricot homolog isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26420826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFSWAP Protein Structure

DRY_EERY

Surp

0
200
400
600
800
951 a.a.

Protein Preferred Names	Protein Names
splicing factor, suppressor of white-apricot homolog	splicing factor SWAP homolog

SFSWAP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SFSWAP	Q12872	CFAP20	Homo sapiens	Q9Y6A4	Anti Tag CoIP	33961781
Intra	SFSWAP	Q12872	SF1	Homo sapiens	Q15637	Pull Down	26420826

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Dominant 41	DFNA41 Autosomal Dominant Nonsyndromic Deafness 41 Autosomal Dominant Deafness 41 Deafness, Autosomal Dominant, 41 Deafness, Autosomal Dominant, Type 41
Pulmonary Subvalvular Stenosis	Pulmonary Infundibular Stenosis Congenital Infundibular Stenosis Infundibular Pulmonic Stenosis Infundibular Pulmonic Stenosis, Congenital Subvalvular Pulmonic Stenosis
Meninges Sarcoma	Meningeal Sarcoma Sarcoma Of Meninges Meningothelial Sarcoma Leptomeningeal Sarcoma
Deafness, Autosomal Dominant 27	DFNA27 Autosomal Dominant Nonsyndromic Deafness 27 Autosomal Dominant Deafness 27 Deafness, Autosomal Dominant, 27
Supraglottis Neoplasm	Neoplasm Of Supraglottis Supraglottic Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12778	SFSWAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SFSWAP	VGNC	VGNC:77188
Mus musculus	SFSWAP	MGD	MGI:101760
Bos taurus	SFSWAP	VGNC	VGNC:34524
Rattus norvegicus	SFSWAP	RGD	RGD:1305004
Felis catus	SFSWAP	VGNC	VGNC:65065
Canis familiaris	SFSWAP	VGNC	VGNC:46084
Others	SFSWAP	NCBI