SPANXD - SPANX family member D Gene

Also Known as CT11.3; CT11.4; SPANXC; SPANXE; SPANX-C; SPANX-D; SPANX-E; dJ171K16.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64648

About SPANXD

Cytogenetic location: Xq27.2 Genomic coordinates (GRCh38): X:141,697,411-141,698,739 (from NCBI)

This gene has 1 transcript (splice variant), 3 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 8.6).

Summary

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of Cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate Cancer susceptibility. [provided by RefSeq, Apr 2014]

SPANXD Products (1)

mRNA Protein Name
NM_032417.4 NP_115793.1 sperm protein associated with the nucleus on the X chromosome D

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPANXD Protein Structure

SPAN-X

SPAN-X: Sperm protein associated with nucleus, mapped to X chromosome (1 - 96)

  • 0
  • 97 a.a.
Protein Preferred Names Protein Names

sperm protein associated with the nucleus on the X chromosome D

  • Cancer/testis antigen 11.3

SPANXD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPANXD Q9BXN6 SETBP1 Homo sapiens Q9Y6X0-2
Validated Y2H
32296183
Intra
SPANXD Q9BXN6 SETBP1 Homo sapiens Q9Y6X0-2
Y2H Prey Pooling
32296183
Intra
SPANXD Q9BXN6 SETBP1 Homo sapiens Q9Y6X0-2
Y2H Array
32296183
Intra
SPANXD Q9BXN6 SETBP1 Homo sapiens Q9Y6X0
Y2H Prey Pooling
25416956
Intra
SPANXD Q9BXN6 FLNA Homo sapiens P21333-2
Y2H Prey Pooling
32296183
Intra
SPANXD Q9BXN6 FLNA Homo sapiens P21333-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13630 SPANXD Human Pre-designed siRNA Set A Pre-designed Set / Unkown