UNKL - unk like zinc finger Gene

Also Known as ZC3H5L; C16orf28; ZC3HDC5L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64718

About UNKL

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,363,205-1,414,704 (from NCBI)

This gene has 18 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 4.2), endometrium (RPKM 4.2) and 25 other tissues.

Summary

This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

UNKL Products (7)

mRNA Protein Name
NM_001037125.4 NP_001032202.1 putative E3 ubiquitin-protein ligase UNKL isoform 2
NM_001193388.4 NP_001180317.2 putative E3 ubiquitin-protein ligase UNKL isoform 1
NM_001193389.2 NP_001180318.1 putative E3 ubiquitin-protein ligase UNKL isoform 4
NM_001276414.2 NP_001263343.1 putative E3 ubiquitin-protein ligase UNKL isoform 5
NM_001367622.1 NP_001354551.1 putative E3 ubiquitin-protein ligase UNKL isoform 3
NM_001370526.1 NP_001357455.1 putative E3 ubiquitin-protein ligase UNKL isoform 6
NM_001372107.1 NP_001359036.1 putative E3 ubiquitin-protein ligase UNKL isoform 7

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20148946 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNKL Protein Structure

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (292 - 308)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (637 - 675)

  • 0
  • 200
  • 400
  • 600
  • 680 a.a.
Protein Preferred Names Protein Names

putative E3 ubiquitin-protein ligase UNKL

  • RING finger protein unkempt-like

UNKL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UNKL Q9H9P5 SMARCD2 Homo sapiens Q92925
Pull Down
20148946
Intra
UNKL Q9H9P5 RAC1 Homo sapiens P63000
Y2H
20148946
Intra
UNKL Q9H9P5 RAC1 Homo sapiens P63000
Pull Down
20148946
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15480 UNKL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UNKL RGD RGD:1565247
Canis familiaris UNKL VGNC VGNC:54086
Mus musculus UNKL MGD MGI:1921404
Bos taurus UNKL VGNC VGNC:58618
Macaca mulatta UNKL VGNC VGNC:99625
Felis catus UNKL VGNC VGNC:66838
Others UNKL NCBI