MTARC1 - mitochondrial amidoxime reducing component 1 Gene

Also Known as MARC1; MOSC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64757

About MTARC1

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:220,786,913-220,819,659 (from NCBI)

This gene has 16 transcripts (splice variants), 125 orthologues and 2 paralogues. Biased expression in fat (RPKM 66.4), thyroid (RPKM 15.8) and 6 other tissues.

Summary

Enables molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on Other nitrogenous compounds as donors. Contributes to nitrite reductase (NO-forming) activity. Involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion. Part of nitric-oxide synthase complex. [provided by Alliance of Genome Resources, Apr 2022]

MTARC1 Products (1)

mRNA Protein Name
NM_022746.4 NP_073583.3 mitochondrial amidoxime-reducing component 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molybdenum ion binding IDA
IDA: Inferred from direct assay
20861021 GOA
enables molybdopterin cofactor binding IDA
IDA: Inferred from direct assay
20861021 GOA
enables nitrate reductase activity IDA
IDA: Inferred from direct assay
20861021 GOA
contributes to nitrite reductase (NO-forming) activity IDA
IDA: Inferred from direct assay
24500710 GOA
enables nitrite reductase activity IDA
IDA: Inferred from direct assay
24500710 GOA
enables oxidoreductase activity, acting on other nitrogenous compounds as donors IDA
IDA: Inferred from direct assay
25713076 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular detoxification of nitrogen compound IMP
IMP: Inferred from mutant phenotype
25713076 GOA
involved in nitrate metabolic process IDA
IDA: Inferred from direct assay
20861021 GOA
involved in nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
24500710 GOA
Cellular Component GO Annotation Evidence References Source
part of nitric-oxide synthase complex IDA
IDA: Inferred from direct assay
24500710 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTARC1 Protein Structure

MOSC_N

MOSC_N: MOSC N-terminal beta barrel domain (56 - 175)

MOSC

MOSC: MOSC domain (202 - 333)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
Protein Preferred Names Protein Names

mitochondrial amidoxime-reducing component 1

  • MOCO sulphurase C-terminal domain containing 1

MTARC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MTARC1 Q5VT66 NAA11 Homo sapiens Q9BSU3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08750 MTARC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MTARC1 VGNC VGNC:31235
Mus musculus MTARC1 MGD MGI:1913362
Rattus norvegicus MTARC1 RGD RGD:1592219
Canis familiaris MTARC1 VGNC VGNC:43013
Others MTARC1 NCBI