2. Gene
  3. MRPL1 - mitochondrial ribosomal protein L1 Gene

MRPL1 - mitochondrial ribosomal protein L1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as L1MT; BM022; MRP-L1

Gene ID: 65008 | Gene type: protein coding

About MRPL1

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:77,862,830-77,952,785 (from NCBI)

This gene has 6 transcripts (splice variants) and 161 orthologues. Ubiquitous expression in kidney (RPKM 8.5), heart (RPKM 8.4) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008]

MRPL1 Products(1)

mRNA Protein Name
NM_020236.4 NP_064621.3 39S ribosomal protein L1, mitochondrial precursor

MRPL1 Protein Structure

(12 - 160)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

39S ribosomal protein L1, mitochondrial

mitochondrial large ribosomal subunit protein uL1m

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08662 MRPL1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MRPL1 MGD MGI:2137202
Bos taurus MRPL1 VGNC VGNC:31614
Rattus norvegicus MRPL1 RGD RGD:1306850
Canis familiaris MRPL1 VGNC VGNC:43375
Felis catus MRPL1 VGNC VGNC:63590