Nherf2 - NHERF family PDZ scaffold protein 2 Gene

Also Known as Sip1; Octs2; Sip-1; Tka-1; E3karp; Sryip1; NHERF-2; Slc9a3r2; 0610011L07Rik; 1200011K07Rik; 2010007A20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 65962

Summary

Enables Phosphatase binding activity. Acts upstream of or within negative regulation of phosphatidylinositol 3-kinase signaling and sensory perception of sound. Located in several cellular components, including apical plasma membrane; nucleus; and stereocilium. Is expressed in cochlea epithelium and organ of Corti. Orthologous to human SLC9A3R2 (SLC9A3 regulator 2). [provided by Alliance of Genome Resources, Apr 2022]

Nherf2 Products (3)

mRNA Protein Name
NM_001357796.1 NP_001344725.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform C
NM_023055.2 NP_075542.2 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform A
NM_023449.3 NP_075938.2 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatase binding IPI
IPI: Inferred from physical interaction
16456542 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10410901 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
16456542 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
16456542 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
24920589 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12169661 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10410901 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10410901 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
24920589 MGI
located in stereocilium bundle IDA
IDA: Inferred from direct assay
24920589 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF2

  • NHE3 kinase A regulatory protein E3KARP

  • SRY-interacting protein 1

  • sodium-hydrogen exchanger regulatory factor 2

  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

  • tyrosine kinase activator protein 1

Nherf2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nherf2 Q9JHL1 Pten Mus musculus O08586
Pull Down
16456542
Intra
Nherf2 Q9JHL1 Pdgfrb Mus musculus P05622
Chromatography
16456542
Intra
Nherf2 Q9JHL1 Pdgfrb Mus musculus P05622
Pull Down
16456542
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09283 NHERF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nherf2 NCBI NCBI:9351