Asph - aspartate-beta-hydroxylase Gene

Also Known as BAH; cI-37; 2310005F16Rik; 3110001L23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 65973

Summary

Predicted to enable calcium ion binding activity and peptidyl-aspartic acid 3-dioxygenase activity. Involved in regulation of protein depolymerization and regulation of protein stability. Acts upstream of or within several processes, including face morphogenesis; limb morphogenesis; and peptidyl-aspartic acid hydroxylation. Located in cytoplasm. Is expressed in several structures, including eye; face; heart; limb; and trunk. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human ASPH (aspartate beta-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Asph Products (11)

mRNA Protein Name
NM_001177849.1 NP_001171320.1 aspartyl/asparaginyl beta-hydroxylase isoform 3
NM_001177850.1 NP_001171321.1 aspartyl/asparaginyl beta-hydroxylase isoform 4
NM_001177851.1 NP_001171322.1 aspartyl/asparaginyl beta-hydroxylase isoform 5
NM_001177852.1 NP_001171323.1 aspartyl/asparaginyl beta-hydroxylase isoform 6
NM_001177853.1 NP_001171324.1 aspartyl/asparaginyl beta-hydroxylase isoform 7
NM_001177854.1 NP_001171325.1 aspartyl/asparaginyl beta-hydroxylase isoform 9
NM_001177855.1 NP_001171326.1 aspartyl/asparaginyl beta-hydroxylase isoform 8
NM_001177856.1 NP_001171327.1 aspartyl/asparaginyl beta-hydroxylase isoform 10
NM_001290367.1 NP_001277296.1 aspartyl/asparaginyl beta-hydroxylase isoform 11 precursor
NM_023066.3 NP_075553.2 aspartyl/asparaginyl beta-hydroxylase isoform 1
NM_133723.2 NP_598484.2 aspartyl/asparaginyl beta-hydroxylase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22123818 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
11773073 MGI
acts upstream of or within face morphogenesis IMP
IMP: Inferred from mutant phenotype
11773073 MGI
acts upstream of or within limb morphogenesis IMP
IMP: Inferred from mutant phenotype
11773073 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
11773073 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
11773073 MGI
acts upstream of or within peptidyl-aspartic acid hydroxylation IDA
IDA: Inferred from direct assay
11773073 MGI
involved in regulation of protein depolymerization IDA
IDA: Inferred from direct assay
22123818 MGI
involved in regulation of protein stability IDA
IDA: Inferred from direct assay
22123818 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
11773073 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22123818 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aspartyl/asparaginyl beta-hydroxylase

  • ASP beta-hydroxylase

  • aspartly beta-hydroxylase

  • aspartyl beta-hydroxylase Humbug

  • calsequestrin-binding protein

  • jumbug

  • junctate

  • junctin

  • peptide-aspartate beta-dioxygenase

Recombinant Asph Proteins

Cat. No. Product Name Accession Purity
HY-P77565 ASPH Protein, Mouse (His) Q8BSY0-1 (I324-I741) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164410 MO-I-1100 Inhibitor 99.76% Unkown
HY-10403A (aS)-PH-797804 Inhibitor / Unkown
HY-146646 Bleomycin A2 99.89% Unkown
HY-160720 ASPH-IN-1 Inhibitor / Unkown
HY-RS01102 ASPH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18464 Asph Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24945 Asph Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asph NCBI NCBI:444