Abhd6 - abhydrolase domain containing 6 Gene

Also Known as 0610041D24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66082

Summary

Enables acylglycerol Lipase activity and Phospholipase activity. Involved in several processes, including monoacylglycerol catabolic process; negative regulation of cold-induced thermogenesis; and phospholipid metabolic process. Acts upstream of or within long-term synaptic depression; negative regulation of cell migration; and regulation of endocannabinoid signaling pathway. Located in late endosome membrane; lysosomal membrane; and mitochondrion. Is integral component of postsynaptic membrane. Part of AMPA glutamate receptor complex. Is active in GABA-ergic synapse and glutamatergic synapse. Orthologous to human ABHD6 (abhydrolase domain containing 6, acylglycerol Lipase). [provided by Alliance of Genome Resources, Apr 2022]

Abhd6 Products (3)

mRNA Protein Name
NM_001331064.1 NP_001317993.1 monoacylglycerol lipase ABHD6 isoform 1
NM_001331065.1 NP_001317994.1 monoacylglycerol lipase ABHD6 isoform 2
NM_025341.4 NP_079617.2 monoacylglycerol lipase ABHD6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables monoacylglycerol lipase activity IDA
IDA: Inferred from direct assay
18096503 MGI
enables monoacylglycerol lipase activity IMP
IMP: Inferred from mutant phenotype
20657592 MGI
enables phospholipase activity IDA
IDA: Inferred from direct assay
24095738 MGI
Biological Process GO Annotation Evidence References Source
involved in acylglycerol catabolic process IDA
IDA: Inferred from direct assay
18096503 MGI
acts upstream of or within long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
20657592 MGI
involved in lysobisphosphatidic acid metabolic process IDA
IDA: Inferred from direct assay
26491015 MGI
involved in monoacylglycerol catabolic process IDA
IDA: Inferred from direct assay
26491015 MGI
acts upstream of or within negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20657592 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
26997277 MGI
involved in phospholipid catabolic process IDA
IDA: Inferred from direct assay
24095738 MGI
involved in positive regulation of lipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
24095738 MGI
acts upstream of or within regulation of endocannabinoid signaling pathway IMP
IMP: Inferred from mutant phenotype
20657592 MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid EXP
EXP: Inferred from Experiment
20657592 MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid IDA
IDA: Inferred from direct assay
20657592 MGI
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
22632720 MGI
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
20657592 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
20657592 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20657592 MGI
located in late endosome membrane IDA
IDA: Inferred from direct assay
26491015 MGI
located in lysosomal membrane IDA
IDA: Inferred from direct assay
26491015 MGI
located in membrane IDA
IDA: Inferred from direct assay
18096503 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
20657592 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
20657592 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

monoacylglycerol lipase ABHD6

  • 2-arachidonoylglycerol hydrolase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136924 FP-Biotin 99.08% Unkown
HY-110148 WWL113 Inhibitor 99.72% Unkown
HY-100337 WWL70 Inhibitor 99.95% Unkown
HY-120177 KT182 Inhibitor 99.77% Unkown
HY-120215 KT203 Inhibitor 99.77% Unkown
HY-125143 ABC34 Inhibitor 99.90% Unkown
HY-152148 JZP-MA-11 Inhibitor 99.26% Unkown
HY-18544 AA38-3 Inhibitor 99.95% Unkown
HY-132310 MAGL-IN-4 Inhibitor 99.79% Unkown
HY-101457 JZP-430 Inhibitor 99.74% Unkown
HY-121422 JZP-361 Inhibitor 99.63% Unkown
HY-124314 LEI-106 Inhibitor 99.9% Unkown
HY-114926 KT185 Inhibitor 99.37% Unkown
HY-132246 WWL123 analogue-1 Inhibitor 98.04% Unkown
HY-103463 SA57 Inhibitor ≥99.0% Unkown
HY-110178 WWL123 Inhibitor 98.0% Unkown
HY-116212 JCP-170 Inhibitor / Unkown
HY-116793 Dimepiperate / Unkown
HY-117722 JW 618 Inhibitor / Unkown
HY-120126 ML378 Inhibitor / Unkown
HY-120171 DH-376 Inhibitor / Unkown
HY-152152 JZP-MA-13 Inhibitor / Unkown
HY-158338 ABHD antagonist 1 Antagonist / Unkown
HY-158339 ABHD antagonist 2 Antagonist / Unkown
HY-184029 PF-7845yne / Unkown
HY-RS00097 ABHD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126031 (R)-KT109 Inhibitor / Unkown
HY-126031A (S)-KT109 / Unkown
HY-RS16727 Abhd6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23163 Abhd6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abhd6 NCBI NCBI:57406