Pbrm1 - polybromo 1 Gene

Also Known as Pb1; BAF180; 2610016F04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66923

Summary

Enables chromatin binding activity. Acts upstream of or within blastocyst formation; heart development; and placenta development. Located in kinetochore. Is expressed in brain; early conceptus; genitourinary system; and heart. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1). [provided by Alliance of Genome Resources, Apr 2022]

Pbrm1 Products (6)

mRNA Protein Name
NM_001081251.1 NP_001074720.1 protein polybromo-1 isoform 1
NM_001359854.1 NP_001346783.1 protein polybromo-1 isoform 2
NM_001359855.1 NP_001346784.1 protein polybromo-1 isoform 3
NM_001359856.1 NP_001346785.1 protein polybromo-1 isoform 4
NM_001359857.1 NP_001346786.1 protein polybromo-1 isoform 5
NM_001359858.1 NP_001346787.1 protein polybromo-1 isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
15601824 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17640523 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst formation IMP
IMP: Inferred from mutant phenotype
27869233 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
15601824 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
15601824 MGI
Cellular Component GO Annotation Evidence References Source
part of SWI/SNF superfamily-type complex IDA
IDA: Inferred from direct assay
24335282 MGI
located in kinetochore IDA
IDA: Inferred from direct assay
14519686 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein polybromo-1

  • 2310032M22Rik

  • BRG1-associated factor 180

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-163410 AU-24118 99.10% Phase 2

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128359 ACBI1 99.92% Unkown
HY-149026 GNE-064 Inhibitor 99.65% Unkown
HY-151532 PBRM1-BD2-IN-5 Inhibitor 99.75% Unkown
HY-150289 GNE-235 98.86% Unkown
HY-151538 PBRM1-BD2-IN-8 Inhibitor 98.05% Unkown
HY-151529 PBRM1-BD2-IN-2 Inhibitor 99.0% Unkown
HY-148381 A947 / Unkown
HY-151528 PBRM1-BD2-IN-1 Inhibitor / Unkown
HY-151530 PBRM1-BD2-IN-3 Inhibitor / Unkown
HY-151531 PBRM1-BD2-IN-4 Inhibitor / Unkown
HY-151533 PBRM1-BD2-IN-6 Inhibitor / Unkown
HY-151534 PBRM1-BD2-IN-7 Inhibitor / Unkown
HY-161881 SMARCA2-IN-9 Inhibitor / Unkown
HY-171774 PBRM1/SMARCA2,4-ligand-1 / Unkown
HY-174237 PBRM1/SMARCA2,4 binder-1 / Unkown
HY-175756 SMARCA2/4 degrader-1 Degrader / Unkown
HY-183007 LJM133 Degrader / Unkown
HY-RS10105 PBRM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17918 Pbrm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24387 Pbrm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pbrm1 NCBI NCBI:55193