SRM - spermidine synthase Gene

Also Known as PAPT; SPS1; SPDSY; SRML1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6723

About SRM

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,054,589-11,060,018 (from NCBI)

This gene has 6 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 19.8), lymph node (RPKM 14.2) and 25 other tissues.

Summary

The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four Enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]

SRM Products (1)

mRNA	Protein	Name
NM_003132.3	NP_003123.2	spermidine synthase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17585781	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17585781	GOA
enables spermidine synthase activity	IDA IDA: Inferred from direct assay	17585781	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in spermidine biosynthetic process	IDA IDA: Inferred from direct assay	17585781	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRM Protein Structure

Spermine_synth

0
100
200
302 a.a.

Protein Preferred Names	Protein Names
spermidine synthase	putrescine aminopropyltransferase

SRM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRM	P19623	SRM	Homo sapiens	P19623	X-Ray Diffraction	17585781
Intra	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Prey Pooling	32296183
Intra	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Array	32296183
Intra	SRM	P19623	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Array	29892012
Intra	SRM	P19623	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	31515488
Intra	SRM	P19623	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Array	31515488
Intra	SRM	P19623	SRM	Homo sapiens	P19623	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Sleeping Sickness	African Trypanosomiasis African Sleeping Sickness Trypanosomiasis, Human East-African Trypanosomiasis, East African Trypanosomiasis African Trypanosomiasis, African Human African Trypanosomiasis
Chagas Disease	American Trypanosomiasis Chagas' Disease Chagas' Disease With Digestive System Involvement Chagas' Disease With Nervous System Involvement Chagas' Disease With Other Organ Involvement Infection Due To Trypanosoma Cruzi South American Trypanosomiasis Chronic Chagas Disease With Digestive System Involvement
Leishmaniasis	Post-Kala-Azar Dermal Leishmaniasis Post Kala-Azar Dermal Leishmaniasis Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis Cutaneous Leishmaniasis Kala-Azar Visceral Leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis, Visceral Leishmania Leishmania Infection Leishmaniosis
Syndromic X-Linked Intellectual Disability Snyder Type	Snyder-Robinson Syndrome Mental Retardation, X-Linked, Snyder-Robinson Type Spermine Synthase Deficiency Srs Snyder-Robinson Mental Retardation Syndrome X-Linked Intellectual Disability Snyder-Robinson Type Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type Snyder-Robinson X-Linked Mental Retardation Syndrome
Secondary Progressive Multiple Sclerosis	Secondary-Progressive Ms Spms Multiple Sclerosis, Chronic Progressive Chronic Progressive Multiple Sclerosis Multiple Sclerosis, Secondary Progressive
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-120111	MW-150	Inhibitor	99.89%	Phase 2

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131028	Janelia Fluor® 646 TFA		97.79%	Unkown
HY-131029	Janelia Fluor® 646, Maleimide		97.50%	Unkown
HY-P3146A	FTISADTSK acetate		99.66%	Unkown
HY-131026	Janelia Fluor® 635, SE		99.30%	Unkown
HY-P3146S	FTISADTSK-13C6,15N2 TFA		96.04%	Unkown
HY-RS13769	SRM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-152901	Chol-N3		/	Unkown
HY-120111A	MW-150 hydrochloride	Inhibitor	/	Unkown
HY-120111B	MW-150 dihydrochloride dihydrate	Inhibitor	/	Unkown
HY-120796	MW108 hydrochloride	Inhibitor	/	Unkown
HY-P3146	FTISADTSK		/	Unkown
HY-RS13770	SRMS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18332	Srm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22333	Srms Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24811	Srm Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28855	Srms Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SRM	VGNC	VGNC:35282
Rattus norvegicus	SRM	RGD	RGD:620796
Mus musculus	SRM	MGD	MGI:102690
Canis familiaris	SRM	VGNC	VGNC:46805
Felis catus	SRM	VGNC	VGNC:82543
Others	SRM	NCBI