Tab2 - TGF-beta activated kinase 1/MAP3K7 binding protein 2 Gene

Also Known as Map3k7ip2; mKIAA0733; 1110030N06Rik; A530078N03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68652

Summary

Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein kinase activity; and response to lipopolysaccharide. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Tab2 Products (2)

mRNA Protein Name
NM_001359534.1 NP_001346463.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
NM_138667.3 NP_619608.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17158449 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

  • TGF-beta-activated kinase 1-binding protein 2

  • Tak1 binding protein 2

  • mitogen-activated protein kinase kinase kinase 7-interacting protein 2

Tab2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Tab2 Q99K90 Map3k7 Mus musculus Q62073
Anti Bait CoIP
17158449
Intra
Tab2 Q99K90 Map3k7 Mus musculus Q62073
Anti Bait CoIP
24270572
Intra
Tab2 Q99K90 Rps27a Mus musculus P62991
X-Ray Diffraction
19927120
Intra
Tab2 Q99K90 Rps27a Mus musculus P62991
Pull Down
19927120
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14134 TAB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19165 Tab2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25654 Tab2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tab2 NCBI NCBI:23118