Pak4 - p21 (RAC1) activated kinase 4 Gene

Also Known as mKIAA1142; 5730488L07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70584

About Pak4

Chromosome 7: 28,258,244-28,297,610 reverse strand.GRCm39:CM001000.3

This gene has 4 transcripts (splice variants), 162 orthologues, 35 paralogues and is associated with 25 phenotypes. Ubiquitous expression in colon adult (RPKM 4.7), duodenum adult (RPKM 33.4) and 25 other tissues.

Summary

Enables protein kinase activity. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Pak4 Products (1)

mRNA Protein Name
NM_027470.3 NP_081746.1 serine/threonine-protein kinase PAK 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein kinase activity IDA
IDA: Inferred from direct assay
23509247 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
23509247 MGI
acts upstream of or within dendritic spine development IGI
IGI: Inferred from genetic interaction
23509247 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pak4 Protein Structure

CRIB_PAK_like

CRIB_PAK_like: cd01093 (9 - 47)

PKc_like

PKc_like: cl21453 (301 - 592)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 593 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 4

  • PAK-4

  • p21 protein (Cdc42/Rac)-activated kinase 4

  • p21-activated kinase 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12793 Padnarsertib Inhibitor 99.58% Phase 2
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19538 FRAX1036 Inhibitor 98.88% Unkown
HY-125035 LCH-7749944 Inhibitor 99.68% Unkown
HY-143490 PAK4-IN-2 Inhibitor 99.42% Unkown
HY-N8389 Globulol Inhibitor 99.74% Unkown
HY-184396 GR2-128 Inhibitor / Unkown
HY-146681 PAK1-IN-1 Inhibitor / Unkown
HY-130628 PAK4-IN-1 Inhibitor / Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-159897 PAK4-IN-5 Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown
HY-183941 SPU-106 Inhibitor / Unkown
HY-111103A CZh226 hydrochloride Inhibitor / Unkown
HY-174247 CPS-021 Degrader / Unkown
HY-111103 CZh226 Inhibitor / Unkown
HY-117218 KY-04045 Inhibitor / Unkown
HY-181092 PAK4-IN-7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pak4 NCBI NCBI:10298