Sik3 - SIK family kinase 3 Gene

Also Known as Qsk; SIK-3; mKIAA0999; 5730525O22Rik; 9030204A07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70661

About Sik3

Chromosome 9: 45,924,118-46,135,492 forward strand.GRCm39:CM001002.3

This gene has 7 transcripts (splice variants), 224 orthologues, 19 paralogues and is associated with 223 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 12.2), adrenal adult (RPKM 1.1) and 28 other tissues.

Summary

Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Acts upstream of or within endochondral bone morphogenesis; limb morphogenesis; and regulation of protein localization. Located in cytoplasm. Is expressed in Meckel's cartilage and vibrissa. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Sik3 Products (1)

mRNA Protein Name
NM_027498.3 NP_081774.3 serine/threonine-protein kinase SIK3

Sik3 Protein Structure

STKc_SIK

STKc_SIK: cd14071 (64 - 316)

UBA_SIK3

UBA_SIK3: cd14410 (345 - 389)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1369 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase SIK3

  • salt-inducible kinase 3

  • serine/threonine-protein kinase QSK

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15776 HG-9-91-01 Inhibitor 99.77% Unkown
HY-101147 YKL-05-099 Inhibitor 99.76% Unkown
HY-120856 ARN-3236 Inhibitor 99.66% Unkown
HY-120877 MRT199665 Inhibitor 99.85% Unkown
HY-N1570 Pterosin B Inhibitor 99.98% Unkown
HY-148061 DB1113 99.86% Unkown
HY-175479 GLPG4970 Inhibitor 99.60% Unkown
HY-139253 MRIA9 Inhibitor 98.88% Unkown
HY-173191 SK-124 Inhibitor 95.0% Unkown
HY-184954 SIK-IN-6 Inhibitor / Unkown
HY-182804 SIK2/3-IN-3 Inhibitor / Unkown
HY-164534 SIK2/3-IN-2 Inhibitor / Unkown
HY-170237 SIK2/3-IN-1 Inhibitor / Unkown
HY-184862 SIK2-IN-5 Inhibitor / Unkown
HY-178014 SIK1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sik3 NCBI NCBI:23387