2. Gene
  3. RIPK1 - receptor interacting serine/threonine kinase 1 Gene

RIPK1 - receptor interacting serine/threonine kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Macaca mulatta
Gene ID: 708013 | Gene type: protein coding

About RIPK1

Primary_assembly 4: 167,019,880-167,049,254 reverse strand.Mmul_10:CM014339.1

This gene has 1 transcript (splice variant), 198 orthologues and 22 paralogues.

RIPK1 Products(13)

mRNA Protein Name
XM_028847886.1 XP_028703719.1 receptor-interacting serine/threonine-protein kinase 1 isoform X4
XM_028847884.1 XP_028703717.1 receptor-interacting serine/threonine-protein kinase 1 isoform X3
XM_001091986.4 XP_001091986.2 receptor-interacting serine/threonine-protein kinase 1 isoform X2
XM_028847882.1 XP_028703715.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1
XM_028847879.1 XP_028703712.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1
XM_028847881.1 XP_028703714.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1
XM_028847880.1 XP_028703713.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1
XM_028847878.1 XP_028703711.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1
XM_028847885.1 XP_028703718.1 receptor-interacting serine/threonine-protein kinase 1 isoform X4
XM_015135439.2 XP_014990925.2 receptor-interacting serine/threonine-protein kinase 1 isoform X4
XM_015135438.2 XP_014990924.2 receptor-interacting serine/threonine-protein kinase 1 isoform X2
XM_028847877.1 XP_028703710.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1
XM_028847883.1 XP_028703716.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1

RIPK1 Protein Structure

STKc_RIP1

STKc_RIP1: cd14027 (22 - 289)

Death_RIP1

Death_RIP1: cd08777 (622 - 707)

  • 0
  • 200
  • 400
  • 600
  • 711 a.a.
Protein Preferred Names Protein Names

receptor-interacting serine/threonine-protein kinase 1

receptor (TNFRSF)-interacting serine-threonine kinase 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148787 Oditrasertib Inhibitor 99.02% Phase 2
Pre-clinical Phase
Bioactive Molecules (56)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14622A Necrostatin 2 racemate Inhibitor 99.57% Unkown
HY-134050 Apostatin-1 Inhibitor 99.64% Unkown
HY-138779 ICCB-19 hydrochloride Inhibitor 99.25% Unkown
HY-14622 Necrostatin 2 Inhibitor 99.78% Unkown
HY-114371 Eclitasertib Inhibitor 99.80% Unkown
HY-N0546 Ligustroflavone Inhibitor 99.90% Unkown
HY-124546 Necrostatin-5 Inhibitor 99.40% Unkown
HY-148297 Ocadusertib Inhibitor 99.57% Unkown
HY-128348 PK68 Inhibitor 99.92% Unkown
HY-153598 LD4172 Degrader 98.32% Unkown
HY-18901 RIPK1-IN-4 Inhibitor 98.89% Unkown
HY-161060 Zharp1-211 Inhibitor 99.15% Unkown
HY-161059 ZB-R-55 Inhibitor 99.39% Unkown
HY-152846 Flizasertib Inhibitor 99.9% Unkown
HY-157039 RIPK1-IN-17 Inhibitor 97.09% Unkown
HY-157456 RIPK1-IN-19 Inhibitor 98.87% Unkown
HY-148365 NecroIr1 Activator 98.53% Unkown
HY-120548 KBU2046 99.52% Unkown
HY-148366 NecroIr2 Activator 98.02% Unkown
HY-149258 KWCN-41 Inhibitor 99.83% Unkown
HY-151873 SZM679 Inhibitor 99.59% Unkown
HY-132203 Necrostatin-34 Inhibitor 98.90% Unkown
HY-175370 PROTAC RIPK1 Degrader-1 Degrader / Unkown
HY-153434 RIP1 kinase inhibitor 4 Inhibitor / Unkown
HY-173185 RIP1-IN-1 Inhibitor / Unkown
HY-173574 RIPK1-IN-31 Modulator / Unkown
HY-153437 PB830 Inhibitor / Unkown
HY-157963 RIPK1-IN-23 Inhibitor / Unkown
HY-179680 RIPK1-IN-38 Inhibitor / Unkown
HY-170232 RIPK1-IN-29 Inhibitor / Unkown
HY-181062 VWK147 Inhibitor / Unkown
HY-160216 RIPK1-IN-18 Inhibitor / Unkown
HY-180806 RIPK1-IN-39 Inhibitor / Unkown
HY-179235 RIPK1-IN-37 Inhibitor / Unkown
HY-W319332 Necrostatin-21 Inhibitor / Unkown
HY-178762S RIPK1-IN-35 Inhibitor / Unkown
HY-178163 Zharp1-163 Inhibitor / Unkown
HY-181944 RIPK1-IN-40 Inhibitor / Unkown
HY-175371 RIPK1-ligand-2 Inhibitor / Unkown
HY-161911 Necroptosis-IN-5 Inhibitor / Unkown
HY-183781 RIPK1-IN-41 Inhibitor / Unkown
HY-169107 RIPK1-IN-25 Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-18899 Nec-3a Inhibitor / Unkown
HY-144276 RIPK1-IN-11 Inhibitor / Unkown
HY-179323 RIPK1-IN-36 Inhibitor / Unkown
HY-162237 RIPK1-IN-22 Inhibitor / Unkown
HY-183564 RIPK1/RIPK3-PPI-IN-1 Inhibitor / Unkown
HY-181596 WJH-C19 Inhibitor 98.65% Unkown
HY-149052 SZM-1209 Inhibitor / Unkown
HY-P10977 Tat-ASIC1a (1-20) (mouse, rat) Inhibitor / Unkown
HY-175007 RIPK1-IN-32 Inhibitor / Unkown
HY-178464 RIPK1-IN-34 Inhibitor / Unkown
HY-146758 RIPK1-IN-14 Inhibitor / Unkown
HY-143726 RIPK1-IN-8 Inhibitor / Unkown
HY-175374 RIPK1 ligand-Linker Conjugate-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens RIPK1 NCBI NCBI:8737
Macaca fascicularis RIPK1 NCBI NCBI:101926590
Canis lupus familiaris RIPK1 NCBI
Mus musculus RIPK1 NCBI NCBI:19766
Rattus norvegicus RIPK1 NCBI NCBI:306886