TNP1 - transition protein 1 Gene

Homo sapiens

Also known as TP1

Gene ID: 7141 | Gene type: protein coding

About TNP1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:216,859,458-216,860,064 (from NCBI)

This gene has 1 transcript (splice variant) and 83 orthologues. Restricted expression toward testis (RPKM 903.2).

Summary

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]

TNP1 Products(1)

mRNA	Protein	Name
NM_003284.4	NP_003275.1	spermatid nuclear transition protein 1

TNP1 Protein Structure

TP1

0
55 a.a.

Protein Preferred Names

Protein Names

spermatid nuclear transition protein 1

STP-1

Related Diseases

Diseases

Alias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome	Germinal Cell Aplasia
Del Castillo Syndrome	SPGFX1
X-Linked Spermatogenic Failure 1	Congenital Absence Of Germinal Epithelium Of Testes

Infertility

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Oligospermia

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14857	TNP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNP1	RGD	RGD:3884
Macaca mulatta	TNP1	VGNC	VGNC:104561
Bos taurus	TNP1	VGNC	VGNC:36197
Canis familiaris	TNP1	VGNC	VGNC:47693
Felis catus	TNP1	VGNC	VGNC:80389
Mus musculus	TNP1	MGD	MGI:98784