TNP1 - transition protein 1 Gene

Also Known as TP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7141

About TNP1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:216,859,458-216,860,064 (from NCBI)

This gene has 1 transcript (splice variant) and 83 orthologues. Restricted expression toward testis (RPKM 903.2).

Summary

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]

TNP1 Products (1)

mRNA Protein Name
NM_003284.4 NP_003275.1 spermatid nuclear transition protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IMP
IMP: Inferred from mutant phenotype
12743712 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
12743712 GOA
involved in flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
10781074 GOA
involved in heterochromatin formation IEP
IEP: Inferred from expression pattern
11315969 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12743712 GOA
involved in nucleosome disassembly IMP
IMP: Inferred from mutant phenotype
10781074 GOA
involved in sexual reproduction IMP
IMP: Inferred from mutant phenotype
10781074 GOA
involved in single strand break repair IDA
IDA: Inferred from direct assay
12743712 GOA
involved in spermatid development IDA
IDA: Inferred from direct assay
12743712 GOA
involved in spermatid nucleus elongation IMP
IMP: Inferred from mutant phenotype
10781074 GOA
Cellular Component GO Annotation Evidence References Source
part of nucleosome IDA
IDA: Inferred from direct assay
12743712 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNP1 Protein Structure

TP1

TP1: Nuclear transition protein 1 (2 - 55)

  • 0
  • 55 a.a.
Protein Preferred Names Protein Names

spermatid nuclear transition protein 1

  • STP-1

TNP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNP1 P09430 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
TNP1 P09430 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
TNP1 P09430 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Intra
TNP1 P09430 SDCBP2 Homo sapiens Q9H190
Y2H Array
31515488
Intra
TNP1 P09430 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
25416956
Intra
TNP1 P09430 SDCBP2 Homo sapiens Q9H190
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Spermatogenic Failure, X-Linked, 1

  • Sertoli Cell-Only Syndrome

  • Germinal Cell Aplasia

  • Del Castillo Syndrome

  • SPGFX1

  • X-Linked Spermatogenic Failure 1

  • Congenital Absence Of Germinal Epithelium Of Testes
Infertility
Pelvic Varices

  • Varix Of Pelvis

  • Pelvic Varicose Vein
Oligospermia
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14857 TNP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNP1 RGD RGD:3884
Macaca mulatta TNP1 VGNC VGNC:104561
Bos taurus TNP1 VGNC VGNC:36197
Canis familiaris TNP1 VGNC VGNC:47693
Felis catus TNP1 VGNC VGNC:80389
Mus musculus TNP1 MGD MGI:98784