Tmem175 - transmembrane protein 175 Gene

Also Known as mTMEM175; 3010001K23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72392

Summary

Enables potassium ion leak channel activity. Involved in lysosome organization; neuron cellular homeostasis; and potassium ion transmembrane transport. Predicted to be integral component of endosome membrane and integral component of lysosomal membrane. Predicted to be active in endosome and lysosome. Orthologous to human TMEM175 (transmembrane protein 175). [provided by Alliance of Genome Resources, Apr 2022]

Tmem175 Products (6)

mRNA Protein Name
NM_001163531.1 NP_001157003.1 endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001163532.1 NP_001157004.1 endosomal/lysosomal potassium channel TMEM175 isoform 1
NM_001359423.1 NP_001346352.1 endosomal/lysosomal potassium channel TMEM175 isoform 1
NM_001359426.1 NP_001346355.1 endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_001359427.1 NP_001346356.1 endosomal/lysosomal potassium channel TMEM175 isoform 4
NM_028223.3 NP_082499.3 endosomal/lysosomal potassium channel TMEM175 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables potassium ion leak channel activity IMP
IMP: Inferred from mutant phenotype
26317472 MGI
Biological Process GO Annotation Evidence References Source
involved in neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
33505021 MGI
involved in phagosome-lysosome fusion IMP
IMP: Inferred from mutant phenotype
26317472 MGI
involved in potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
26317472 MGI
involved in regulation of lysosomal lumen pH IMP
IMP: Inferred from mutant phenotype
26317472 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endosomal/lysosomal potassium channel TMEM175

  • endosomal/lysomomal potassium channel TMEM175

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-33878 2-PPA Inhibitor 99.98% Unkown
HY-161949 AP-6 Inhibitor 99.84% Unkown
HY-162666 TMEM175 modulator 1 Modulator 98.91% Unkown
HY-RS29457 TMEM175 Monkey Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19555 Tmem175 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181621 Tmem175 modulator 2 Modulator / Unkown
HY-181622 TMEM175 modulator 3 Activator / Unkown
HY-182768 TMEM175 modulator-4 Modulator / Unkown
HY-RS14683 TMEM175 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182464 DABMA Activator / Unkown
HY-RS26051 Tmem175 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmem175 NCBI NCBI:84286