Brap - BRCA1 associated protein Gene

Also Known as IMP; BRAP2; 3010002G07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72399

Summary

Predicted to enable identical protein binding activity; nuclear localization sequence binding activity; and ubiquitin protein Ligase activity. Predicted to be involved in negative regulation of signal transduction. Predicted to act upstream of or within MAPK cascade; Ras protein signal transduction; and protein ubiquitination. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be part of ubiquitin Ligase complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and vibrissa. Orthologous to human BRAP (BRCA1 associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Brap Products (3)

mRNA Protein Name
NM_001289543.1 NP_001276472.1 BRCA1-associated protein isoform 2
NM_001289544.1 NP_001276473.1 BRCA1-associated protein isoform 3
NM_028227.3 NP_082503.2 BRCA1-associated protein isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25820252 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

BRCA1-associated protein

  • RING-type E3 ubiquitin transferase BRAP2

  • impedes mitogenic signal propagation

Brap Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Brap Q99MP8 Akap3 Mus musculus O88987
Anti Bait CoIP
25820252
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01591 BRAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18746 Brap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25233 Brap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brap NCBI NCBI:8315