GFUS - GDP-L-fucose synthase Gene

Homo sapiens

Also known as FX; P35B; TSTA3; SDR4E1

Gene ID: 7264 | Gene type: protein coding

About GFUS

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,612,618-143,618,048 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 277 orthologues and 10 paralogues. Ubiquitous expression in stomach (RPKM 48.7), skin (RPKM 31.8) and 25 other tissues.

Summary

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]

GFUS Products(9)

mRNA	Protein	Name
NM_001317783.2	NP_001304712.1	GDP-L-fucose synthase isoform 1
NM_001413407.1	NP_001400336.1	GDP-L-fucose synthase isoform 3
NM_001413408.1	NP_001400337.1	GDP-L-fucose synthase isoform 2
NM_001413409.1	NP_001400338.1	GDP-L-fucose synthase isoform 4
NM_001413410.1	NP_001400339.1	GDP-L-fucose synthase isoform 5
NM_001413411.1	NP_001400340.1	GDP-L-fucose synthase isoform 6
NM_001413412.1	NP_001400341.1	GDP-L-fucose synthase isoform 7
NM_001413413.1	NP_001400342.1	GDP-L-fucose synthase isoform 8
NM_003313.4	NP_003304.1	GDP-L-fucose synthase isoform 2

GFUS Protein Structure

Epimerase

0
100
200
300
321 a.a.

Protein Preferred Names

Protein Names

GDP-L-fucose synthase

3-5 epimerase/4-reductase

Recombinant GFUS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71390	TSTA3 Protein, Human (His)	Q13630 (M1-K321)	≥95%

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 40

RP40	Retinitis Pigmentosa-40
Retinitis Pigmentosa, Type 40

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05391	GFUS Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GFUS	VGNC	VGNC:47933
Bos taurus	GFUS	VGNC	VGNC:36450
Macaca mulatta	GFUS	VGNC	VGNC:78666
Rattus norvegicus	GFUS	RGD	RGD:1307028
Mus musculus	GFUS	MGD	MGI:98857
Felis catus	GFUS	VGNC	VGNC:66648