CDK11A - cyclin dependent kinase 11A Gene

Also Known as CDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 728642

About CDK11A

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,702,379-1,724,357 (from NCBI)

This gene has 23 transcripts (splice variants), 202 orthologues and 26 paralogues. Ubiquitous expression in bone marrow (RPKM 22.4), small intestine (RPKM 18.4) and 25 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

CDK11A Products (4)

mRNA Protein Name
NM_001313896.2 NP_001300825.1 cyclin-dependent kinase 11A isoform 5
NM_001313982.2 NP_001300911.1 cyclin-dependent kinase 11A isoform 3
NM_024011.4 NP_076916.2 cyclin-dependent kinase 11A isoform 1
NM_033529.4 NP_277071.2 cyclin-dependent kinase 11A isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
12501247 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12501247 GOA
Biological Process GO Annotation Evidence References Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12501247 GOA
involved in regulation of RNA splicing IDA
IDA: Inferred from direct assay
12501247 GOA
involved in regulation of cell growth IEP
IEP: Inferred from expression pattern
10882096 GOA
involved in regulation of mRNA processing IDA
IDA: Inferred from direct assay
12501247 GOA
Cellular Component GO Annotation Evidence References Source
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
18216018 GOA
located in nucleus IDA
IDA: Inferred from direct assay
8195233 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK11A Protein Structure

Pkinase

Pkinase: Protein kinase domain (426 - 711)

  • 0
  • 200
  • 400
  • 600
  • 783 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 11A

  • PITSLRE B

CDK11A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDK11A Q9UQ88 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Childhood Endodermal Sinus Tumor

  • Childhood Endodermal Sinus Neoplasm

  • Childhood Endodermal Sinus Tumour

  • Paediatric Yolk Sac Tumour

  • Pediatric Yolk Sac Tumor

  • Childhood Yolk Sac Tumor
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

  • Star Syndrome

  • Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

  • Syndactyly With Renal And Anogenital Malformations

  • STAR

  • Syndactyly, Telecanthus, Anogenital And Renal Malformations

  • Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155874 ZNL-05-044 Inhibitor 99.11% Unkown
HY-RS02352 CDK11A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CDK11A MGD MGI:88353