C8G - complement C8 gamma chain Gene

Homo sapiens

Also known as C8C

Gene ID: 733 | Gene type: protein coding

About C8G

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,945,243-136,946,975 (from NCBI)

This gene has 6 transcripts (splice variants), 165 orthologues and is associated with 1 phenotype. Biased expression in liver (RPKM 36.1), duodenum (RPKM 11.1) and 1 other tissue.

Summary

The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes Complement Component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on Bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated Bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]

C8G Products(1)

mRNA	Protein	Name
NM_000606.3	NP_000597.2	complement component C8 gamma chain precursor

C8G Protein Structure

Lipocalin

0
100
202 a.a.

Protein Preferred Names

Protein Names

complement component C8 gamma chain

complement component 8, gamma polypeptide

Recombinant C8G Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7824	Complement C8G Protein, Human (His)	AAI13627.1 (Q21-R202)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency Due To A Late Component Of Complement Deficiency

Immunodeficiency Due To C5 To C9 Component Complement Deficiency

Terminal Complement Pathway Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01757	C8G Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	C8G	MGD	MGI:88237
Macaca mulatta	C8G	VGNC	VGNC:70481
Felis catus	C8G	VGNC	VGNC:60237
Canis familiaris	C8G	VGNC	VGNC:38602
Rattus norvegicus	C8G	RGD	RGD:1309074
Bos taurus	C8G	VGNC	VGNC:26646
Others	C8G	NCBI