C8G - complement C8 gamma chain Gene

Also Known as C8C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 733

About C8G

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,945,243-136,946,975 (from NCBI)

This gene has 6 transcripts (splice variants), 165 orthologues and is associated with 1 phenotype. Biased expression in liver (RPKM 36.1), duodenum (RPKM 11.1) and 1 other tissue.

Summary

The protein encoded by this gene belongs to the Lipocalin Family. It is one of the three subunits that constitutes Complement Component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on Bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated Bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]

C8G Products (1)

mRNA Protein Name
NM_000606.3 NP_000597.2 complement component C8 gamma chain precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of membrane attack complex IPI
IPI: Inferred from physical interaction
30552328 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C8G Protein Structure

Lipocalin

Lipocalin: Lipocalin / cytosolic fatty-acid binding protein family (48 - 184)

  • 0
  • 100
  • 202 a.a.
Protein Preferred Names Protein Names

complement component C8 gamma chain

  • complement component 8, gamma polypeptide

C8G Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
C8G P07360 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
C8G P07360 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
C8G P07360 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant C8G Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7824 Complement C8G Protein, Human (His, solution) AAI13627.1 (Q21-R202) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Immunodeficiency Due To A Late Component Of Complement Deficiency

  • Immunodeficiency Due To C5 To C9 Component Complement Deficiency

  • Terminal Complement Pathway Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS01757 C8G Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19295 C8g Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25785 C8g Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus C8G MGD MGI:88237
Macaca mulatta C8G VGNC VGNC:70481
Felis catus C8G VGNC VGNC:60237
Canis familiaris C8G VGNC VGNC:38602
Rattus norvegicus C8G RGD RGD:1309074
Bos taurus C8G VGNC VGNC:26646
Others C8G NCBI