Parn - poly(A)-specific ribonuclease (deadenylation nuclease) Gene

Also Known as DAN; 1200003I18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74108

Summary

Predicted to enable several functions, including cation binding activity; poly(A)-specific ribonuclease activity; and protein kinase binding activity. Acts upstream of or within nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in nuclear speck and nucleolus. Predicted to be active in cytoplasm. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 6. Orthologous to human PARN (poly(A)-specific ribonuclease). [provided by Alliance of Genome Resources, Apr 2022]

Parn Products (3)

mRNA Protein Name
NM_001358452.1 NP_001345381.1 poly(A)-specific ribonuclease PARN isoform 2
NM_001358453.1 NP_001345382.1 poly(A)-specific ribonuclease PARN isoform 3
NM_028761.3 NP_083037.1 poly(A)-specific ribonuclease PARN isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18337750 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within nuclear-transcribed mRNA poly(A) tail shortening IDA
IDA: Inferred from direct assay
18337750 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

poly(A)-specific ribonuclease PARN

  • polyadenylate-specific ribonuclease

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137817 BCH001 Inhibitor 98.72% Unkown
HY-158970 Caf1-IN-1 Inhibitor 99.44% Unkown
HY-RS10046 PARN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18630 Parn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25116 Parn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parn NCBI NCBI:5073