ZNF224 - zinc finger protein 224 Gene

Also Known as BMZF2; KOX22; ZNF27; BMZF-2; ZNF255

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7767

Summary

This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in Glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]
Ubiquitous expression in spleen (RPKM 8.7), lymph node (RPKM 7.2) and 25 other tissues.

ZNF224 Products (1)

mRNA Protein Name
NG_051221.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12527367 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20587513 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12527367 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
20587513 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12527367 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
20587513 GOA
part of transcription repressor complex IDA
IDA: Inferred from direct assay
20587513 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF224 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF224 Q9NZL3 MAGEA8 Homo sapiens P43361
Y2H Prey Pooling
32296183
Intra
ZNF224 Q9NZL3 MAGEA8 Homo sapiens P43361
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16112 ZNF225 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16114 ZNF24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16116 ZNF274 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29506 ZNF22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown