CSDE1 - cold shock domain containing E1 Gene

Also Known as UNR; D1S155E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7812

About CSDE1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,716,916-114,757,984 (from NCBI)

This gene has 53 transcripts (splice variants), 240 orthologues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 208.0), thyroid (RPKM 164.2) and 25 other tissues.

Summary

Enables RNA stem-loop binding activity. Involved in IRES-dependent viral translational initiation; nuclear-transcribed mRNA catabolic process, no-go decay; and stress granule assembly. Located in Golgi apparatus; cytosol; and plasma membrane. Part of CRD-mediated mRNA stability complex. [provided by Alliance of Genome Resources, Apr 2022]

CSDE1 Products (6)

mRNA Protein Name
NM_001007553.3 NP_001007554.1 cold shock domain-containing protein E1 isoform 1
NM_001130523.3 NP_001123995.1 cold shock domain-containing protein E1 isoform 3
NM_001242891.2 NP_001229820.1 cold shock domain-containing protein E1 isoform 4
NM_001242892.2 NP_001229821.1 cold shock domain-containing protein E1 isoform 1
NM_001242893.2 NP_001229822.1 cold shock domain-containing protein E1 isoform 2
NM_007158.6 NP_009089.4 cold shock domain-containing protein E1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RISC complex binding IDA
IDA: Inferred from direct assay
32161113 GOA
enables RNA stem-loop binding IDA
IDA: Inferred from direct assay
17947529 GOA
enables lncRNA binding IPI
IPI: Inferred from physical interaction
36354136 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in CRD-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
11051545 GOA
involved in IRES-dependent viral translational initiation IDA
IDA: Inferred from direct assay
17947529 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
11051545 GOA
involved in nuclear-transcribed mRNA catabolic process, no-go decay IMP
IMP: Inferred from mutant phenotype
15314026 GOA
involved in positive regulation of cytoplasmic translation IDA
IDA: Inferred from direct assay
11051545 GOA
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
36354136 GOA
involved in stress granule assembly IMP
IMP: Inferred from mutant phenotype
29395067 GOA
Cellular Component GO Annotation Evidence References Source
part of CRD-mediated mRNA stability complex IDA
IDA: Inferred from direct assay
15314026 GOA
located in cytosol IDA
IDA: Inferred from direct assay
11051545 GOA
part of mCRD-mediated mRNA stability complex IPI
IPI: Inferred from physical interaction
11051545 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSDE1 Protein Structure

CSD

CSD: 'Cold-shock' DNA-binding domain (73 - 135)

CSD

CSD: 'Cold-shock' DNA-binding domain (232 - 293)

CSD

CSD: 'Cold-shock' DNA-binding domain (397 - 457)

CSD

CSD: 'Cold-shock' DNA-binding domain (567 - 627)

CSD

CSD: 'Cold-shock' DNA-binding domain (721 - 783)

SUZ-C

SUZ-C: SUZ-C motif (802 - 835)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 844 a.a.
Protein Preferred Names Protein Names

cold shock domain-containing protein E1

  • N-ras upstream gene protein

CSDE1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CSDE1 O75534 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
CSDE1 O75534 HID1 Homo sapiens Q8IV36
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

CSDE1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83083 CSDE1 Antibody (YA2828) WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P83083A CSDE1 Antibody (YA2828)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human

Related Diseases

Diseases Alias
Bulbar Polio

  • Poliomyelitis, Bulbar

  • Bulbar Poliomyelitis
Persistent Generalized Lymphadenopathy

  • Pgl

  • Persistant Generalized Lymphadenopathy
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03225 CSDE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21542 Csde1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28060 Csde1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CSDE1 VGNC VGNC:39650
Macaca mulatta CSDE1 VGNC VGNC:71605
Felis catus CSDE1 VGNC VGNC:61213
Mus musculus CSDE1 MGD MGI:92356
Rattus norvegicus CSDE1 RGD RGD:619726
Bos taurus CSDE1 VGNC VGNC:27751
Others CSDE1 NCBI