CYREN - cell cycle regulator of NHEJ Gene

Also Known as MRI; MRI-2; C7orf49

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 78996

About CYREN

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,092,303-135,172,469 (from NCBI)

This gene has 14 transcripts (splice variants) and 96 orthologues. Ubiquitous expression in lung (RPKM 6.0), spleen (RPKM 6.0) and 25 other tissues.

Summary

Involved in double-strand break repair via nonhomologous end joining and negative regulation of double-strand break repair via nonhomologous end joining. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CYREN Products (11)

mRNA Protein Name
NM_001243749.2 NP_001230678.1 cell cycle regulator of non-homologous end joining isoform 2
NM_001243751.2 NP_001230680.1 cell cycle regulator of non-homologous end joining isoform 2
NM_001243752.2 NP_001230681.1 cell cycle regulator of non-homologous end joining isoform 2
NM_001243753.2 NP_001230682.1 cell cycle regulator of non-homologous end joining isoform 2
NM_001243754.2 NP_001230683.1 cell cycle regulator of non-homologous end joining isoform 3
NM_001243755.2 NP_001230684.1 cell cycle regulator of non-homologous end joining isoform 3
NM_001305629.2 NP_001292558.1 cell cycle regulator of non-homologous end joining isoform 4
NM_001305630.2 NP_001292559.1 cell cycle regulator of non-homologous end joining isoform 5
NM_001363329.2 NP_001350258.1 cell cycle regulator of non-homologous end joining isoform 1
NM_001363330.2 NP_001350259.1 cell cycle regulator of non-homologous end joining isoform 1
NM_024033.4 NP_076938.2 cell cycle regulator of non-homologous end joining isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24610814 GOA
Biological Process GO Annotation Evidence References Source
involved in double-strand break repair via nonhomologous end joining IDA
IDA: Inferred from direct assay
24610814 GOA
involved in negative regulation of double-strand break repair via nonhomologous end joining IDA
IDA: Inferred from direct assay
28959974 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24610814 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24610814 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYREN Protein Structure

MRI

MRI: Modulator of retrovirus infection (52 - 157)

  • 0
  • 100
  • 157 a.a.
Protein Preferred Names Protein Names

cell cycle regulator of non-homologous end joining

  • modulator of retrovirus infection homolog

CYREN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CYREN Q9BWK5 MKLN1 Homo sapiens Q9UL63
Validated Y2H
32296183
Intra
CYREN Q9BWK5 ERCC6L2 Homo sapiens Q5T890
Y2H Array
32296183
Intra
CYREN Q9BWK5 ERCC6L2 Homo sapiens Q5T890
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Petrositis

  • Acute Petrositis

  • Chronic Petrositis

  • Inflammation Of Petrous Bone

  • Osteitis Of Petrous Bone

  • Osteomyelitis Of Petrous Bone
Epilepsy, Familial Temporal Lobe, 3

  • Epilepsy, Familial Mesial Temporal Lobe

  • Fmtle

  • Familial Temporal Lobe Epilepsy 3

  • ETL3

  • Familial Mesial Temporal Lobe Epilepsy
Bn2 Diffuse Large B-Cell Lymphoma

  • Bn2 Dlbcl

  • Doid:0081064
Telangiectatic Osteogenic Sarcoma

  • Telangiectatic Osteosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03490 CYREN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22464 Cyren Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28987 Cyren Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CYREN VGNC VGNC:59049
Macaca mulatta CYREN VGNC VGNC:81301
Rattus norvegicus CYREN RGD RGD:1563238
Bos taurus CYREN VGNC VGNC:52721
Mus musculus CYREN MGD MGI:1925662
Felis catus CYREN VGNC VGNC:102031
Others CYREN NCBI