AUNIP - aurora kinase A and ninein interacting protein Gene

Also Known as AIBP; C1orf135

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79000

About AUNIP

This gene has 3 transcripts (splice variants) and 91 orthologues. Broad expression in testis (RPKM 11.8), adrenal (RPKM 7.3) and 24 other tissues.

Summary

Enables damaged DNA binding activity. Involved in double-strand break repair via homologous recombination; negative regulation of double-strand break repair via nonhomologous end joining; and spindle organization. Located in centrosome; site of DNA damage; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

AUNIP Products (2)

mRNA Protein Name
NM_001287490.2 NP_001274419.1 aurora kinase A and ninein-interacting protein isoform 1
NM_024037.3 NP_076942.1 aurora kinase A and ninein-interacting protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables damaged DNA binding IDA
IDA: Inferred from direct assay
29042561 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20596670 GOA
Biological Process GO Annotation Evidence References Source
involved in double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
29042561 GOA
involved in negative regulation of double-strand break repair via nonhomologous end joining IDA
IDA: Inferred from direct assay
29042561 GOA
involved in spindle organization IMP
IMP: Inferred from mutant phenotype
20596670 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
20596670 GOA
located in site of DNA damage IDA
IDA: Inferred from direct assay
29042561 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
20596670 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AUNIP Protein Structure

AIB

AIB: Aurora kinase A and ninein interacting protein (26 - 350)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
Protein Preferred Names Protein Names

aurora kinase A and ninein-interacting protein

  • aurora A-binding protein

AUNIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AUNIP Q9H7T9 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
Intra
AUNIP Q9H7T9 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
Intra
AUNIP Q9H7T9 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
Intra
AUNIP Q9H7T9 TRIM68 Homo sapiens Q6AZZ1
Anti Tag CoIP
33961781
Intra
AUNIP Q9H7T9 TRIM68 Homo sapiens Q6AZZ1
Anti Tag CoIP
28514442
Intra
AUNIP Q9H7T9 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra
AUNIP Q9H7T9 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra
AUNIP Q9H7T9 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra
AUNIP Q9H7T9 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
AUNIP Q9H7T9 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
AUNIP Q9H7T9 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
AUNIP Q9H7T9 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
AUNIP Q9H7T9 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
AUNIP Q9H7T9 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
AUNIP Q9H7T9 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
AUNIP Q9H7T9 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
AUNIP Q9H7T9 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
AUNIP Q9H7T9 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra
AUNIP Q9H7T9 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra
AUNIP Q9H7T9 DR1 Homo sapiens Q01658
Validated Y2H
32814053
Intra
AUNIP Q9H7T9 DR1 Homo sapiens Q01658
Y2H Array
32814053
Intra
AUNIP Q9H7T9 DR1 Homo sapiens Q01658
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Apocrine Carcinoma

  • Apocrine Carcinoma Of Breast

  • Apocrine Breast Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01264 AUNIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21492 Aunip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28010 Aunip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus AUNIP MGD MGI:1917135
Rattus norvegicus AUNIP RGD RGD:1589922
Canis familiaris AUNIP VGNC VGNC:38309
Bos taurus AUNIP VGNC VGNC:26347
Felis catus AUNIP VGNC VGNC:60041
Macaca mulatta AUNIP VGNC VGNC:70140
Others AUNIP NCBI