WDR25 - WD repeat domain 25 Gene

Also Known as C14orf67

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79446

About WDR25

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:100,376,485-100,530,303 (from NCBI)

This gene has 11 transcripts (splice variants), 193 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 3.8), testis (RPKM 2.7) and 25 other tissues.

Summary

This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

WDR25 Products (6)

mRNA	Protein	Name
NM_001161476.3	NP_001154948.1	WD repeat-containing protein 25 isoform a
NM_001350947.2	NP_001337876.1	WD repeat-containing protein 25 isoform a
NM_001350948.2	NP_001337877.1	WD repeat-containing protein 25 isoform a
NM_001350949.2	NP_001337878.1	WD repeat-containing protein 25 isoform b
NM_001387351.1	NP_001374280.1	WD repeat-containing protein 25 isoform b
NM_024515.6	NP_078791.3	WD repeat-containing protein 25 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR25 Protein Structure

WD40

0
100
200
300
400
500
544 a.a.

Protein Preferred Names	Protein Names
WD repeat-containing protein 25	epididymis secretory sperm binding protein

WDR25 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WDR25	Q64LD2	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	WDR25	Q64LD2	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	WDR25	Q64LD2	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	WDR25	Q64LD2	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	WDR25	Q64LD2	CCT7	Homo sapiens	Q99832	Anti Tag CoIP	28514442
Intra	WDR25	Q64LD2	CCT7	Homo sapiens	Q99832	Anti Tag CoIP	33961781
Intra	WDR25	Q64LD2	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	WDR25	Q64LD2	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma	DMSMFH Bone Dysplasia With Medullary Fibrosarcoma Bdmf Bone Dysplasia With Malignant Fibrous Histiocytoma Hardcastle Syndrome Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome Myopathy, Limb-Girdle, With Bone Fragility Bone Dysplasia-Medullary Fibrosarcoma Syndrome Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome Dms-Mfh Limb-Girdle Myopathy With Bone Fragility Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma
Rapidly Involuting Congenital Hemangioma	Rich

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15769	WDR25 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	WDR25	VGNC	VGNC:36888
Felis catus	WDR25	VGNC	VGNC:67022
Macaca mulatta	WDR25	VGNC	VGNC:78420
Canis familiaris	WDR25	VGNC	VGNC:48357
Rattus norvegicus	WDR25	RGD	RGD:1562505
Mus musculus	WDR25	MGD	MGI:3045255
Others	WDR25	NCBI