NEK11 - NIMA related kinase 11 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79858

About NEK11

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:131,026,877-131,350,465 (from NCBI)

This gene has 17 transcripts (splice variants), 169 orthologues and 8 paralogues. Broad expression in testis (RPKM 4.2), thyroid (RPKM 2.7) and 22 other tissues.

Summary

This gene encodes a member of the never in Mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

NEK11 Products (33)

mRNA Protein Name
NM_001146003.2 NP_001139475.1 serine/threonine-protein kinase Nek11 isoform 3
NM_001321220.2 NP_001308149.1 serine/threonine-protein kinase Nek11 isoform 1
NM_001321221.2 NP_001308150.1 serine/threonine-protein kinase Nek11 isoform 4
NM_001321222.2 NP_001308151.1 serine/threonine-protein kinase Nek11 isoform 5
NM_001321223.1 NP_001308152.1 serine/threonine-protein kinase Nek11 isoform 6
NM_001321224.2 NP_001308153.1 serine/threonine-protein kinase Nek11 isoform 7
NM_001353022.2 NP_001339951.1 serine/threonine-protein kinase Nek11 isoform 4
NM_001353023.2 NP_001339952.1 serine/threonine-protein kinase Nek11 isoform 1
NM_001353024.2 NP_001339953.1 serine/threonine-protein kinase Nek11 isoform 8
NM_001353025.2 NP_001339954.1 serine/threonine-protein kinase Nek11 isoform 8
NM_001353026.2 NP_001339955.1 serine/threonine-protein kinase Nek11 isoform 9
NM_001353027.2 NP_001339956.1 serine/threonine-protein kinase Nek11 isoform 10
NM_001353028.2 NP_001339957.1 serine/threonine-protein kinase Nek11 isoform 3
NM_001353029.2 NP_001339958.1 serine/threonine-protein kinase Nek11 isoform 3
NM_001353030.2 NP_001339959.1 serine/threonine-protein kinase Nek11 isoform 11
NM_001353031.2 NP_001339960.1 serine/threonine-protein kinase Nek11 isoform 11
NM_001353032.2 NP_001339961.1 serine/threonine-protein kinase Nek11 isoform 5
NM_001353033.2 NP_001339962.1 serine/threonine-protein kinase Nek11 isoform 12
NM_001353034.2 NP_001339963.1 serine/threonine-protein kinase Nek11 isoform 12
NM_001353036.2 NP_001339965.1 serine/threonine-protein kinase Nek11 isoform 13
NM_001353037.2 NP_001339966.1 serine/threonine-protein kinase Nek11 isoform 14
NM_001353038.2 NP_001339967.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353039.2 NP_001339968.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353040.2 NP_001339969.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353041.2 NP_001339970.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353042.2 NP_001339971.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353043.2 NP_001339972.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353044.2 NP_001339973.1 serine/threonine-protein kinase Nek11 isoform 16
NM_001353045.2 NP_001339974.1 serine/threonine-protein kinase Nek11 isoform 16
NM_001353046.2 NP_001339975.1 serine/threonine-protein kinase Nek11 isoform 7
NM_001353048.2 NP_001339977.1 serine/threonine-protein kinase Nek11 isoform 17
NM_024800.5 NP_079076.3 serine/threonine-protein kinase Nek11 isoform 1
NM_145910.4 NP_665917.1 serine/threonine-protein kinase Nek11 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
15161910 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15161910 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15161910 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
15161910 GOA
involved in mitotic intra-S DNA damage checkpoint signaling IDA
IDA: Inferred from direct assay
15161910 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15161910 GOA
involved in regulation of mitotic cell cycle phase transition IMP
IMP: Inferred from mutant phenotype
12154088 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
15161910 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK11 Protein Structure

Pkinase

Pkinase: Protein kinase domain (29 - 287)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 645 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek11

  • NIMA (never in mitosis gene a)- related kinase 11

NEK11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NEK11 Q8NG66 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra
NEK11 Q8NG66 NEK2 Homo sapiens P51955
Anti Bait CoIP
15161910
Intra
NEK11 Q8NG66 NEK2 Homo sapiens P51955
IF
15161910
Intra
NEK11 Q8NG66 NEK2 Homo sapiens P51955
Protein Kinase Assay
15161910
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly

  • Majewski Syndrome

  • SRTD6

  • Srps2a

  • Short Rib-Polydactyly Syndrome, Majewski Type

  • Polydactyly With Neonatal Chondrodystrophy, Type Ii

  • Short Rib-Polydactyly Syndrome Type Iia

  • Short Rib-Polydactyly Syndrome Type 2

  • Short Rib-Polydactyly Syndrome Type Ii

  • Short Rib-Polydactyly Syndrome, Type Ii

  • Srps, Type Ii

  • Short Rib-Polydactyly Syndrome, Type Iia

  • Polydactyly With Neonatal Chondrodystrophy Type 2

  • Srps Type 2

  • Short Rib-Polydactyly Syndrome Majewski Type

  • Polydactyly With Neonatal Chondrodystrophy Type Ii

  • Short Rib-Polydactyly Syndrome 2a

  • Srps Type Ii
Melanoma, Cutaneous Malignant 1

  • Familial Melanoma

  • Melanoma, Cutaneous Malignant, Susceptibility To, 1

  • Melanoma, Malignant

  • CMM1

  • Melanoma, Cutaneous Malignant

  • Cmm

  • Familial Atypical Mole-Malignant Melanoma Syndrome

  • Fammm

  • Melanoma, Familial

  • Mlm

  • Dysplastic Nevus Syndrome, Hereditary

  • Dns

  • B-K Mole Syndrome

  • Melanoma, Cutaneous Malignant, 1

  • Malignant Melanoma, Cutaneous

  • Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

  • Dysplastic Nevus Syndrome

  • Cutaneous Melanoma

  • Familial Atypical Mole Melanoma Syndrome

  • Hereditary Melanoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09192 NEK11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20063 Nek11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26567 Nek11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NEK11 MGD MGI:2442276
Felis catus NEK11 VGNC VGNC:102788
Bos taurus NEK11 VGNC VGNC:53591
Rattus norvegicus NEK11 RGD RGD:1308801
Canis familiaris NEK11 VGNC VGNC:52894
Others NEK11 NCBI