DENND1C - DENN domain containing 1C Gene

Also Known as FAM31C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79958

Summary

The protein encoded by this gene functions as a Guanine Nucleotide exchange factor for the early endosomal small GTPase RAB35, which regulates endosomal membrane trafficking and is involved in Actin polymerization. The encoded protein activates RAB35 by promoting the exchange of RAB35-bound GDP for GTP. This gene may play a role in linking RAB35 activation with the Clathrin machinery. [provided by RefSeq, May 2017]
Broad expression in lymph node (RPKM 22.3), spleen (RPKM 19.6) and 19 other tissues.

DENND1C Products (1)

mRNA Protein Name
NG_054762.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
20937701 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DENND1C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DENND1C Q8IV53 SNAPIN Homo sapiens O95295
Y2H Array
32296183
Intra
DENND1C Q8IV53 SNAPIN Homo sapiens O95295
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03689 DENND4C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03685 DENND1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03686 DENND1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown