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MZT2B - mitotic spindle organizing protein 2B Gene

Also Known as FAM128B; MOZART2B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80097

About MZT2B

Cytogenetic location: 2q21.1 Genomic coordinates (GRCh38): 2:130,181,654-130,204,793 (from NCBI)

This gene has 9 transcripts (splice variants), 186 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 10.8), colon (RPKM 10.5) and 25 other tissues.

Summary

Located in cytosol; microtubule cytoskeleton; and nucleoplasm. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]

MZT2B Products (3)

mRNA	Protein	Name
NM_001330282.2	NP_001317211.1	mitotic-spindle organizing protein 2B isoform 1
NM_001330284.2	NP_001317213.1	mitotic-spindle organizing protein 2B isoform 3
NM_025029.5	NP_079305.2	mitotic-spindle organizing protein 2B isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20360068	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	20360068	GOA
part of gamma-tubulin ring complex	IDA IDA: Inferred from direct assay	20360068	GOA
located in spindle	IDA IDA: Inferred from direct assay	20360068	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MZT2B Protein Structure

MOZART2

0
100
158 a.a.

Protein Preferred Names	Protein Names
mitotic-spindle organizing protein 2B	family with sequence similarity 128, member B

MZT2B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MZT2B	Q6NZ67	TUBG1	Homo sapiens	P23258	Anti Tag CoIP	33961781
Intra	MZT2B	Q6NZ67	TUBG1	Homo sapiens	P23258	Anti Tag CoIP	28514442
Intra	MZT2B	Q6NZ67	TUBG1	Homo sapiens	P23258	TAP	20360068

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Charcot-Marie-Tooth Disease Type 2a2b	Severe Early-Onset Axonal Neuropathy Due To Mfn2 Deficiency Ar-Cmt2, Ouvrier Type Autosomal Recessive Charcot-Marie-Tooth Disease, Ouvrier Type Seoan Due To Mfn2 Deficiency Charcot-Marie-Tooth Disease, Axonal, Type 2a2b Cmt2a2b Charcot-Marie-Tooth Disease, Type 2a2b
Clear Cell Meningioma
Neuropathy, Hereditary Sensory And Autonomic, Type Vi	Hereditary Sensory And Autonomic Neuropathy Type 6 HSAN6 Hsan Vi Hereditary Sensory And Autonomic Neuropathy Type Vi Familial Dysautonomia With Contractures Neuropathy, Hereditary Sensory And Autonomic, 6 Hereditary Sensory Neuropathy Type Vi Hsn Vi Neuropathy, Sensory And Autonomic, Hereditary, Type Vi

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08978	MZT2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MZT2B	MGD	MGI:1922845