VOPP1 - VOPP1 WW domain binding protein Gene

Also Known as ECOP; GASP; WBP1L2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81552

About VOPP1

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:55,434,964-55,572,502 (from NCBI)

This gene has 17 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in lymph node (RPKM 19.1), appendix (RPKM 14.7) and 25 other tissues.

Summary

Located in cytoplasmic vesicle membrane and endosome. Is integral component of organelle membrane. [provided by Alliance of Genome Resources, Apr 2022]

VOPP1 Products (13)

mRNA Protein Name
NM_001284282.2 NP_001271211.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 2
NM_001284283.2 NP_001271212.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 3
NM_001284284.1 NP_001271213.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 4
NM_001321242.1 NP_001308171.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 5
NM_001321243.2 NP_001308172.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 6 precursor
NM_001321244.2 NP_001308173.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 7
NM_001321246.2 NP_001308175.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 8 precursor
NM_001321247.2 NP_001308176.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 9 precursor
NM_001321248.2 NP_001308177.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 10 precursor
NM_001321249.2 NP_001308178.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 11 precursor
NM_001321250.2 NP_001308179.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 11 precursor
NM_001321251.1 NP_001308180.1 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 11 precursor
NM_030796.5 NP_110423.3 vesicular, overexpressed in cancer, prosurvival protein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
30285739 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30285739 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
20571887 GOA
located in late endosome IDA
IDA: Inferred from direct assay
30285739 GOA
located in lysosome IDA
IDA: Inferred from direct assay
30285739 GOA
located in organelle membrane IDA
IDA: Inferred from direct assay
20571887 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicular, overexpressed in cancer, prosurvival protein 1

  • EGFR-coamplified and overexpressed protein

VOPP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VOPP1 Q96AW1 WWOX Homo sapiens Q9NZC7
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15668 VOPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus VOPP1 VGNC VGNC:80754
Mus musculus VOPP1 MGD MGI:2141658
Macaca mulatta VOPP1 VGNC VGNC:79950
Canis familiaris VOPP1 VGNC VGNC:54387
Rattus norvegicus VOPP1 RGD RGD:1306494
Bos taurus VOPP1 VGNC VGNC:49588
Others VOPP1 NCBI