ATIC - Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81643

Summary

Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in several processes, including animal organ development; folic acid-containing compound metabolic process; and nucleobase-containing small molecule metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Apr 2022]

ATIC Products (1)

mRNA Protein Name
NM_031014.2 NP_112276.2 bifunctional purine biosynthesis protein ATIC

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables IMP cyclohydrolase activity IDA
IDA: Inferred from direct assay
9332377 RGD
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IDA
IDA: Inferred from direct assay
9332377 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
25687571 RGD
Biological Process GO Annotation Evidence References Source
involved in 'de novo' IMP biosynthetic process IDA
IDA: Inferred from direct assay
9332377 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
9332377 RGD
involved in brainstem development IEP
IEP: Inferred from expression pattern
7057182 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
7057182 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
7057182 RGD
involved in dihydrofolate metabolic process IDA
IDA: Inferred from direct assay
8948466 RGD
involved in tetrahydrofolate biosynthetic process IDA
IDA: Inferred from direct assay
7057182 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional purine biosynthesis protein ATIC

  • AICAR transformylase/inosine monophosphate cyclohydrolase

  • bifunctional purine biosynthesis protein PURH

  • bifunctional purine biosynthesis protein PURH-like

ATIC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Atic O35567 P15127-PRO_0000016698 Rattus norvegicus P15127-PRO_0000016698
Anti Bait CoIP
25687571
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0485 Liensinine Diperchlorate Inhibitor 99.96% Phase 2
HY-135238 (rel)-RSD 921 Agonist / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990067 Evunzekibart Inhibitor 97.02% Phase 1

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0499 Cyanidin Chloride Inhibitor 99.43% Unkown
HY-W011927 4,4'-Sulfonyldiphenol 99.81% Unkown
HY-150252A ATIC-IN-1 acetate 99.96% Unkown
HY-133157 FAICAR 85.81% Unkown
HY-N1448 Vincetoxicoside B Inhibitor 99.70% Unkown
HY-29244 ATIC-IN-2 Inhibitor 98.0% Unkown
HY-150252 ATIC-IN-1 99.69% Unkown
HY-N0499A Cyanidin Inhibitor / Unkown
HY-RS01156 ATIC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-141324 Tetraethyl butane-​1,​4-​diylbis(phosphoramid​ate) / Unkown
HY-178468 PARP1-IN-47 Inhibitor / Unkown
HY-182246 MC2050 Inhibitor / Unkown
HY-N17727 Divaricatol / Unkown
HY-N20707 Castalagin / Unkown
HY-RS01126 ATE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-136263 Biotin-NAD+ Substrate / Unkown
HY-RS17124 Atic Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23569 Atic Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ATIC NCBI NCBI:471