Pde2a - phosphodiesterase 2A Gene

Also Known as Pde2; Pde2a2; CGS-PDE

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81743

About Pde2a

Primary_assembly 1: 155,813,180-155,915,434 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 215 orthologues, 20 paralogues and is associated with 9 phenotypes. Biased expression in Brain (RPKM 258.3), Adrenal (RPKM 218.3) and 8 other tissues.

Summary

Enables identical protein binding activity. Involved in several processes, including establishment of endothelial barrier; negative regulation of cAMP-mediated signaling; and response to hydrogen sulfide. Located in several cellular components, including hippocampal mossy fiber; membrane raft; and mitochondrion. Biomarker of cardiomyopathy. Orthologous to human PDE2A (phosphodiesterase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Pde2a Products (3)

mRNA Protein Name
NM_001270604.2 NP_001257533.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1
NM_001143847.2 NP_001137319.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3
NM_031079.2 NP_112341.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
12573460 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17329248 RGD
Biological Process GO Annotation Evidence References Source
involved in establishment of endothelial barrier IDA
IDA: Inferred from direct assay
20139324 RGD
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
28463107 RGD
involved in negative regulation of cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
12107056 RGD
involved in regulation of mitochondrion organization IMP
IMP: Inferred from mutant phenotype
28463107 RGD
involved in response to hydrogen sulfide IEP
IEP: Inferred from expression pattern
24012591 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19506089 RGD
located in hippocampal mossy fiber IDA
IDA: Inferred from direct assay
19506089 RGD
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28463107 RGD
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
21724846 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
28463107 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
28463107 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
28463107 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
12573460 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde2a Protein Structure

GAF

GAF: smart00065 (234 - 381)

GAF

GAF: smart00065 (403 - 552)

PDEase_I

PDEase_I: pfam00233 (649 - 882)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 935 a.a.
Protein Preferred Names Protein Names

cGMP-dependent 3',5'-cyclic phosphodiesterase

  • cyclic GMP-stimulated phosphodiesterase

  • phosphodiesterase 2A, cGMP-stimulated

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-111167 AN-2898 Inhibitor / Phase 2
HY-111371 PF-05180999 Inhibitor 99.96% Phase 1
HY-103493 TAK-915 Inhibitor 99.57% Phase 1

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-102050 PF-05085727 Inhibitor 99.53% Unkown
HY-132993 Hcyb1 Inhibitor 98.20% Unkown
HY-U00427 PDE2A-IN-3 Inhibitor 99.88% Unkown
HY-102043 PDM-631 Inhibitor / Unkown
HY-112704 PDE5-IN-2 Inhibitor / Unkown
HY-120710 DNS-8254 Inhibitor / Unkown
HY-142660 PDE2A-IN-1 Inhibitor / Unkown
HY-168966 JNJ-54082730 / Unkown
HY-180526 PDE2A-IN-2 Inhibitor / Unkown
HY-RS10213 PDE2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10214 Pde2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10215 Pde2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124173 PF-06815189 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde2a NCBI NCBI:5138