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Ccl5 - C-C motif chemokine ligand 5 Gene

Also Known as Scya5; Rantes

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81780

Summary

Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to organonitrogen compound; lymphocyte migration; and positive regulation of leukocyte chemotaxis. Located in extracellular space. Used to study Chagas disease; bronchiolitis obliterans; kidney disease; non-alcoholic fatty liver disease; and orchitis. Biomarker of several diseases, including alcoholic hepatitis; artery disease (multiple); cardiac arrest; lung disease (multiple); and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5). [provided by Alliance of Genome Resources, Apr 2022]

Ccl5 Products (1)

mRNA	Protein	Name
NM_031116.3	NP_112378.2	C-C motif chemokine 5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	11069838	RGD
enables heparin binding	IDA IDA: Inferred from direct assay	21052646	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in T-helper 1 cell diapedesis	IDA IDA: Inferred from direct assay	10477596	RGD
involved in cellular response to alkyl hydroperoxide	IEP IEP: Inferred from expression pattern	18478184	RGD
involved in cellular response to amino acid stimulus	IEP IEP: Inferred from expression pattern	20560880	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	19111021	RGD
involved in cellular response to ethanol	IEP IEP: Inferred from expression pattern	19828633	RGD
involved in cellular response to high density lipoprotein particle stimulus	IEP IEP: Inferred from expression pattern	20623482	RGD
involved in cellular response to lipid	IEP IEP: Inferred from expression pattern	20638371	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	20578038	RGD
involved in cellular response to morphine	IEP IEP: Inferred from expression pattern	20578038	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	20429874	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	20663893	RGD
involved in cellular response to vitamin K	IEP IEP: Inferred from expression pattern	19291322	RGD
involved in chronic inflammatory response	IEP IEP: Inferred from expression pattern	17164972	RGD
involved in dibenzo-p-dioxin metabolic process	IEP IEP: Inferred from expression pattern	20059583	RGD
involved in lymphocyte chemotaxis	IDA IDA: Inferred from direct assay	11069838	RGD
involved in positive regulation of T cell chemotaxis	IDA IDA: Inferred from direct assay	10477596	RGD
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	18392345	RGD
involved in positive regulation of fever generation	IDA IDA: Inferred from direct assay	15066130	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	19497618	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19559698	RGD
involved in positive regulation of mast cell chemotaxis	IDA IDA: Inferred from direct assay	18052723	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	19559698	RGD
involved in positive regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	9920817	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	10477596	RGD
involved in pseudopodium assembly	IDA IDA: Inferred from direct assay	10477596	RGD
involved in regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	19497618	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	18464247	RGD
involved in response to alcohol	IEP IEP: Inferred from expression pattern	11388697	RGD
involved in response to bacterium	IEP IEP: Inferred from expression pattern	18390738	RGD
involved in response to cholesterol	IEP IEP: Inferred from expression pattern	20435353	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	16251240	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	20435353	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	18476425	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	12435855	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19104678	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	19194968	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18375833	RGD
involved in response to salt stress	IEP IEP: Inferred from expression pattern	20232302	RGD
involved in response to type II interferon	IDA IDA: Inferred from direct assay	10477596	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16987901	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18208670	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
C-C motif chemokine 5	SIS-delta T-cell-specific protein RANTES chemokine (C-C motif) ligand 5 regulated upon activation normal T-cell expressed and secreted small-inducible cytokine A5

Recombinant Ccl5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7761	RANTES/CCL5 Protein, Rat (His)	P50231 (S25-S92)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74602	RANTES/CCL5 Protein, Rat (P.pastoris, His)	P50231 (S25-S92)	≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-152293	EVT801	Inhibitor	/	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990638	NI-0701		99.74%	Phase 1

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15589	GW9508		99.23%	Unkown
HY-122891	SB02024		99.70%	Unkown
HY-152956	STING agonist-23	Agonist	99.33%	Unkown
HY-152959	STING agonist-26	Agonist	99.56%	Unkown
HY-181654	Snail IN-1	Inhibitor	98.27%	Unkown
HY-P1949A	Cyclic MKEY TFA		98.47%	Unkown
HY-147660	IMMH001	Agonist	98.10%	Unkown
HY-145491	Resolvin D5	Inhibitor	98.3%	Unkown
HY-N12110	SMU-CX1	Inhibitor	99.9%	Unkown
HY-15589R	GW9508 (Standard)		98.07%	Unkown
HY-10109A	AS-605240 potassium	Inhibitor	/	Unkown
HY-111198	YM-355179 fumarate		/	Unkown
HY-152957	STING agonist-24	Agonist	/	Unkown
HY-152958	STING agonist-25	Agonist	/	Unkown
HY-152961	STING agonist-28	Agonist	/	Unkown
HY-175290	Arf1-GEFs-IN-1	Inhibitor	/	Unkown
HY-178053	AHR agonist 10		/	Unkown
HY-182926	Topoisomerase I/II-IN-9	Inhibitor	/	Unkown
HY-N17963	Cappariloside A	Inhibitor	/	Unkown
HY-P1949	Cyclic MKEY		/	Unkown
HY-P5836	Citrullinated LL-37 1cit	Inhibitor	/	Unkown
HY-P5837	Citrullinated LL-37 2cit	Inhibitor	/	Unkown
HY-P5838	Citrullinated LL-37 5cit	Inhibitor	/	Unkown
HY-P5843	Citrullinated LL-37 4cit	Inhibitor	/	Unkown
HY-RS02105	CCL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174751	Human CCL5 mRNA		/	Unkown
HY-RS16535	Ccl5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22966	Ccl5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991753	Anti-Mouse CCL5 Antibody (R6G9)	Inhibitor	97.24%	Unkown
HY-P990677	VLST-002	Inhibitor	/	Unkown
HY-P991989	MRG004A Antibody		95.44%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccl5	NCBI	NCBI:6352