CAPZA2 - capping actin protein of muscle Z-line subunit alpha 2 Gene

Also Known as CAPZ; CAPPA2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 830

About CAPZA2

Cytogenetic location: 7q31.2 Genomic coordinates (GRCh38): 7:116,862,587-116,922,049 (from NCBI)

This gene has 14 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 60.8), urinary bladder (RPKM 54.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]

CAPZA2 Products (1)

mRNA Protein Name
NM_006136.3 NP_006127.1 F-actin-capping protein subunit alpha-2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30361697 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPZA2 Protein Structure

F-actin_cap_A

F-actin_cap_A: F-actin capping protein alpha subunit (12 - 282)

  • 0
  • 100
  • 200
  • 286 a.a.
Protein Preferred Names Protein Names

F-actin-capping protein subunit alpha-2

  • F-actin capping protein alpha-2 subunit

Recombinant CAPZA2 Proteins

Cat. No. Product Name Accession Purity
HY-P72116 CAPZA2 Protein, Human (His-SUMO) P47755 (A2-A286) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01903 CAPZA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20532 Capza2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27041 Capza2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CAPZA2 VGNC VGNC:70538
Mus musculus CAPZA2 MGD MGI:106222
Canis familiaris CAPZA2 VGNC VGNC:38711
Felis catus CAPZA2 VGNC VGNC:69365
Bos taurus CAPZA2 VGNC VGNC:26757
Rattus norvegicus CAPZA2 RGD RGD:1549770
Others CAPZA2 NCBI