Vdac1 - voltage-dependent anion channel 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83529

Summary

Enables voltage-gated anion channel activity. Involved in mitochondrial calcium ion transmembrane transport. Located in mitochondrial outer membrane and synaptic vesicle. Part of protein-containing complex. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in prostate Cancer. Orthologous to human VDAC1 (voltage dependent anion channel 1). [provided by Alliance of Genome Resources, Apr 2022]

Vdac1 Products (1)

mRNA Protein Name
NM_031353.2 NP_112643.1 voltage-dependent anion-selective channel protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables monoatomic anion channel activity IDA
IDA: Inferred from direct assay
12438411 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9843949 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
9459579 RGD
enables voltage-gated channel activity IDA
IDA: Inferred from direct assay
450112 RGD
enables voltage-gated monoatomic anion channel activity IDA
IDA: Inferred from direct assay
12438411 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
11485562 RGD
involved in mitochondrial calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
12438411 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
12438411 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
10208569 RGD
is active in presynaptic active zone membrane EXP
EXP: Inferred from Experiment
19187093 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
19187093 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
9459579 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
19187093 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent anion-selective channel protein 1

  • VDAC-1

  • outer mitochondrial membrane protein porin 1

  • rVDAC1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-129122 VBIT-4 Inhibitor 99.29% Unkown
HY-D0086 DIDS sodium salt Inhibitor 99.13% Unkown
HY-135885 VBIT-12 Inhibitor 98.87% Unkown
HY-108937 NSC 15364 Inhibitor 99.88% Unkown
HY-129139 Cyanidin-3-O-arabinoside Inhibitor 95.71% Unkown
HY-176745 SW016789 Inducer 99.85% Unkown
HY-182243 HK2-IN-4 Inhibitor / Unkown
HY-181529 NCATS-SM0225 Ligand / Unkown
HY-121693 DIDS Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vdac1 NCBI NCBI:7416