RHNO1 - RAD9-HUS1-RAD1 interacting nuclear orphan 1 Gene

Also Known as RHINO; C12orf32; HKMT1188

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83695

Summary

Enables chromatin-protein adaptor activity. Involved in several processes, including DNA repair; cellular response to radiation; and regulation of cell cycle process. Located in chromosome and nucleus. Is active in chromatin and site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in thyroid (RPKM 7.6), lymph node (RPKM 7.3) and 25 other tissues.

RHNO1 Products (4)

mRNA Protein Name
NM_001252499.3 NP_001239428.1 RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 1
NM_001252500.3 NP_001239429.1 RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 2
NM_001257097.2 NP_001244026.1 RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 1
NM_001257098.2 NP_001244027.1 RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin-protein adaptor activity IDA
IDA: Inferred from direct assay
37440612 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21659603 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage checkpoint signaling IDA
IDA: Inferred from direct assay
25602520 GOA
involved in DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
21659603 GOA
involved in cellular response to UV IDA
IDA: Inferred from direct assay
21659603 GOA
involved in cellular response to ionizing radiation IDA
IDA: Inferred from direct assay
21659603 GOA
involved in double-strand break repair via alternative nonhomologous end joining IDA
IDA: Inferred from direct assay
37440612 GOA
involved in positive regulation of G0 to G1 transition IMP
IMP: Inferred from mutant phenotype
20811708 GOA
involved in protein localization to site of double-strand break IDA
IDA: Inferred from direct assay
37440612 GOA
involved in recombinational repair IMP
IMP: Inferred from mutant phenotype
21659603 GOA
Cellular Component GO Annotation Evidence References Source
is active in chromatin IDA
IDA: Inferred from direct assay
25602520 GOA
located in chromosome IDA
IDA: Inferred from direct assay
21659603 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20811708 GOA
is active in site of double-strand break IDA
IDA: Inferred from direct assay
37440612 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHNO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RHNO1 Q9BSD3 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
RHNO1 Q9BSD3 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
RHNO1 Q9BSD3 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
RHNO1 Q9BSD3 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra
RHNO1 Q9BSD3 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
Intra
RHNO1 Q9BSD3 TFIP11 Homo sapiens Q9UBB9
BFG-2H
27107012
Intra
RHNO1 Q9BSD3 BACE2 Homo sapiens Q9Y5Z0
Y2H Pooling
32814053
Intra
RHNO1 Q9BSD3 BACE2 Homo sapiens Q9Y5Z0
Validated Y2H
32814053
Intra
RHNO1 Q9BSD3 BACE2 Homo sapiens Q9Y5Z0
Y2H Array
32814053
Intra
RHNO1 Q9BSD3 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
RHNO1 Q9BSD3 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
RHNO1 Q9BSD3 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
RHNO1 Q9BSD3 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
RHNO1 Q9BSD3 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
RHNO1 Q9BSD3 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction