KCNK16 - potassium two pore domain channel subfamily K member 16 Gene

Also Known as TALK1; TALK-1; K2p16.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83795

Summary

The protein encoded by this gene belongs to the family of Potassium Channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the Pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Biased expression in stomach (RPKM 3.5), Pancreas (RPKM 1.4) and 2 other tissues.

KCNK16 Products (5)

mRNA Protein Name
NM_001135105.2 NP_001128577.1 potassium channel subfamily K member 16 isoform 1
NM_001135106.2 NP_001128578.1 potassium channel subfamily K member 16 isoform 3
NM_001135107.2 NP_001128579.1 potassium channel subfamily K member 16 isoform 4
NM_001363784.1 NP_001350713.1 potassium channel subfamily K member 16 isoform 5
NM_032115.4 NP_115491.1 potassium channel subfamily K member 16 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables outward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
26919430 GOA
enables potassium channel activity IDA
IDA: Inferred from direct assay
11263999 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in endoplasmic reticulum calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
28928238 GOA
acts upstream of or within potassium ion transport IDA
IDA: Inferred from direct assay
11263999 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
28928238 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNK16 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
KCNK16 Q96T55 OTX1 Homo sapiens P32242
Y2H Prey Pooling
25416956
Intra
KCNK16 Q96T55 OTX1 Homo sapiens P32242
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07143 KCNJ16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07152 KCNK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07153 KCNK10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07154 KCNK12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07155 KCNK13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07156 KCNK17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07157 KCNK18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07162 KCNK6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21612 Kcnk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28130 Kcnk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown