2. Gene
  3. EIF2A - eukaryotic translation initiation factor 2A Gene

EIF2A - eukaryotic translation initiation factor 2A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CDA02; EIF-2A; MST089; MSTP004; MSTP089

Gene ID: 83939 | Gene type: protein coding

About EIF2A

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:150,546,787-150,586,016 (from NCBI)

This gene has 16 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in thyroid (RPKM 30.8), ovary (RPKM 23.5) and 25 other tissues.

Summary

This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

EIF2A Products(5)

mRNA Protein Name
NM_001319043.2 NP_001305972.1 eukaryotic translation initiation factor 2A isoform 2
NM_001319044.2 NP_001305973.1 eukaryotic translation initiation factor 2A isoform 3
NM_001319045.2 NP_001305974.1 eukaryotic translation initiation factor 2A isoform 4
NM_001319046.2 NP_001305975.1 eukaryotic translation initiation factor 2A isoform 5
NM_032025.5 NP_114414.2 eukaryotic translation initiation factor 2A isoform 1

EIF2A Protein Structure

eIF2A

eIF2A: Eukaryotic translation initiation factor eIF2A (216 - 411)

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  • 585 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 2A

65 kDa eukaryotic translation initiation factor 2A

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119240 CCT020312 Activator 99.28% Unkown
HY-101991 ML291 99.74% Unkown
HY-145835A (S)-PERK-IN-5 Inhibitor / Unkown
HY-RS04241 EIF2A Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EIF2A RGD RGD:1589591
Bos taurus EIF2A VGNC VGNC:28379
Felis catus EIF2A VGNC VGNC:61769
Mus musculus EIF2A MGD MGI:1098684
Canis familiaris EIF2A VGNC VGNC:40255
Macaca mulatta EIF2A VGNC VGNC:72180
Others EIF2A NCBI