ML291
Based on 1 Customer Validation
ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.80%
- CAS 番号: 1523437-16-2
- 分子式: C16H16ClN3O6S
- 分子量:413.83
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保管条件:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Covalent Screening Library
HY-L036
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Endoplasmic Reticulum Stress Compound Library
HY-L054
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Heterocyclic Compound Library
HY-L138
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Cell Death Library
HY-L162
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Covalent Screening Library Plus
HY-L036P
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
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eIF2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IMR-90 | EC50 |
>25 μM
Compound: 8
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Cytotoxicity against human IMR90 cells after 44 to 46 hrs by CellTiter-Blue assay
Cytotoxicity against human IMR90 cells after 44 to 46 hrs by CellTiter-Blue assay
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[PMID: 28119024] |
| MEF | EC50 |
>20 μM
Compound: 12
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Antiproliferative activity against CHOP-knock out MEF cells after 16 hrs by luminescence assay
Antiproliferative activity against CHOP-knock out MEF cells after 16 hrs by luminescence assay
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[PMID: 25530830] |
| MEF | EC50 |
4.8 μM
Compound: 12
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Antiproliferative activity against wild-type MEF cells after 16 hrs by luminescence assay
Antiproliferative activity against wild-type MEF cells after 16 hrs by luminescence assay
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[PMID: 25530830] |
化学情報
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CAS 番号 1523437-16-2
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性状 Solid
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分子量 413.83
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分子式 C16H16ClN3O6S
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Color Off-white to light yellow
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SMILES
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(S(=O)(N3CCC(Cl)CC3)=O)C=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
DMSO : ≥ 50 mg/mL (120.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4165 mL | 12.0823 mL | 24.1645 mL | 60.4113 mL |
| 5 mM | 0.4833 mL | 2.4165 mL | 4.8329 mL | 12.0823 mL | |
| 10 mM | 0.2416 mL | 1.2082 mL | 2.4165 mL | 6.0411 mL | |
| 15 mM | 0.1611 mL | 0.8055 mL | 1.6110 mL | 4.0274 mL | |
| 20 mM | 0.1208 mL | 0.6041 mL | 1.2082 mL | 3.0206 mL | |
| 25 mM | 0.0967 mL | 0.4833 mL | 0.9666 mL | 2.4165 mL | |
| 30 mM | 0.0805 mL | 0.4027 mL | 0.8055 mL | 2.0137 mL | |
| 40 mM | 0.0604 mL | 0.3021 mL | 0.6041 mL | 1.5103 mL | |
| 50 mM | 0.0483 mL | 0.2416 mL | 0.4833 mL | 1.2082 mL | |
| 60 mM | 0.0403 mL | 0.2014 mL | 0.4027 mL | 1.0069 mL | |
| 80 mM | 0.0302 mL | 0.1510 mL | 0.3021 mL | 0.7551 mL | |
| 100 mM | 0.0242 mL | 0.1208 mL | 0.2416 mL | 0.6041 mL |
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