CAPNS2 - calpain small subunit 2 Gene

Also Known as CSS2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84290

About CAPNS2

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,566,684-55,567,687 (from NCBI)

This gene has 1 transcript (splice variant), 223 orthologues and 20 paralogues.

Summary

Enables calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CAPNS2 Products (1)

mRNA Protein Name
NM_032330.3 NP_115706.1 calpain small subunit 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
17646163 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPNS2 Protein Structure

EF-hand_8

EF-hand_8: EF-hand domain pair (92 - 148)

  • 0
  • 100
  • 200
  • 248 a.a.
Protein Preferred Names Protein Names

calpain small subunit 2

  • calcium-dependent protease small subunit 2

CAPNS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAPNS2 Q96L46 CMTM5 Homo sapiens Q96DZ9-2
Y2H Array
32296183
Intra
CAPNS2 Q96L46 CMTM5 Homo sapiens Q96DZ9-2
Y2H Prey Pooling
32296183
Intra
CAPNS2 Q96L46 PHACTR3 Homo sapiens Q96KR7
Y2H Prey Pooling
32296183
Intra
CAPNS2 Q96L46 PHACTR3 Homo sapiens Q96KR7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01889 CAPN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01896 CAPNS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18379 Capn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24859 Capn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CAPNS2 RGD RGD:1583620
Mus musculus CAPNS2 MGD MGI:1916793