Cd40lg - CD40 ligand Gene

Also Known as Cd40l; Tnfsf5

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 84349

Summary

Enables CD40 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of MHC class II biosynthetic process; and positive regulation of cytokine production. Located in several cellular components, including cell body; cell surface; and extracellular space. Used to study Ehrlich tumor carcinoma; artery disease (multiple); autoimmune disease (multiple); thrombosis; and vitamin B12 deficiency. Biomarker of atherosclerosis; coronary artery disease; perinatal necrotizing enterocolitis; periodontal disease; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); hematologic Cancer (multiple); and lupus nephritis. Orthologous to human CD40LG (CD40 ligand). [provided by Alliance of Genome Resources, Apr 2022]

Cd40lg Products (1)

mRNA	Protein	Name
NM_053353.2	NP_445805.2	CD40 ligand

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CD40 receptor binding	IPI IPI: Inferred from physical interaction	18262271	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	26095681	RGD
involved in dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	18384807	RGD
involved in positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	18384807	RGD
involved in positive regulation of MHC class II biosynthetic process	IDA IDA: Inferred from direct assay	18262271	RGD
involved in positive regulation of dendritic cell differentiation	IDA IDA: Inferred from direct assay	18384807	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	17922253	RGD
involved in positive regulation of immune response to tumor cell	IDA IDA: Inferred from direct assay	19016771	RGD
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	18262271	RGD
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	18384807	RGD
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	18262271	RGD
involved in response to cobalamin	IEP IEP: Inferred from expression pattern	16716410	RGD
involved in response to peptide	IEP IEP: Inferred from expression pattern	26840743	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell body	IDA IDA: Inferred from direct assay	25972624	RGD
located in cell projection	IDA IDA: Inferred from direct assay	25972624	RGD
located in cell surface	IDA IDA: Inferred from direct assay	16425979	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16716410	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
CD40 ligand	CD40 ligand CD154 CD40-L tumor necrosis factor ligand superfamily member 5

Recombinant Cd40lg Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74294	CD40L/CD154/TRAP Protein, Rat (HEK293, Fc)	Q9Z2V2/NP_445805.1 (G115-L260)	≥ 80%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02247	CD40LG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174737	Human CD40LG mRNA		/	Unkown
HY-RS17669	Cd40lg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24130	Cd40lg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd40lg	NCBI	NCBI:959
Mus musculus	Cd40lg	NCBI	NCBI:21947
Leporidae	Cd40lg	NCBI
Macaca mulatta	Cd40lg	NCBI	NCBI:574160